Abstract
Micro-electro-mechanical systems (MEMS) technology is applied to produce microneedles for a transdermal drug delivery system (DDS). The microneedle fabrications based on MEMS technologies are classified into three types. The first is the silicon (Si) microneedle fabrication based on the basic MEMS technologies composed of photolithography and etching processes. The second process applies abrasive mechanical machining and anisotropic wet etching technologies in the Si microneedle fabrications to reduce the investment cost. To enhance the safety in use, the third process introduces a metal and a polymer as the needle materials in the microneedle fabrication. Biodegradable microneedle fabrication described here as an example of what is now commonly used. First, the shapes of the microneedles are designed and fabricated in a Si substrate by photolithography and wet etching technologies. The fabricated Si needles are then molded by polydimethylsiloxane to make them biodegradable. A mixture of two materials, for example a hyaluronic acid and a collagen, is used as the needle material, and different shaped biodegradable pyramidal needles are produced by molding processes. It is possible to produce a sharp needle tip with a radius of less than 0.003 mm made of the biodegradable material, even if the molding process is used in the microneedle fabrications. A sharp tip separable microneedle device has also been developed to inject medicine into the skin precisely and immediately.
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Part of this work was supported by JSPS KAKENHI Grant Number 26600060, Japan.
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Shikida, M. (2017). Microneedle Array. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_15
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DOI: https://doi.org/10.1007/978-4-431-56526-0_15
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