Abstract
The skin has been used as an administration route for medicine for many years. When the transdermal application of a compound is considered, it is difficult to deliver it inside the body through the stratum corneum. Therefore, many researchers have examined the percutaneous penetration-enhancing method. One method using liposomes has been considered. Liposomes can function not only as a transdermal absorption enhancement method but also as a controlled-release method.
Recently, new types of liposomes that include non-ionic detergent or ethanol in the membrane are gaining attention, as are phospholipid liposomes. These new vehicles are called elastic liposomes, and are promising candidates for new strategies to enhance the effectiveness of percutaneously applied compounds. Here we review recent advances and future perspectives of liposomes as percutaneous drug carriers.
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References
Bangham AD, Standish MM, Watkins JC (1965) Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13:238–252
Gamal MM, El Maghraby, Williams AC, Barry BW (2006) Can drug-bearing liposomes penetrate intact skin? J Pharm Pharmacol and Pharmacology 58:415–429
Cevc G, Blume G (1992) Lipid vesicles penetrate into intact skin owing to the transdermal osmotic gradients and hydration force. Biochim Biophys Acta 1104:226–232
El Maghraby GM, Williams AC, Barry BW (2001) Skin delivery of 5-fluorouracil from ultradeformable and standard liposomes in-vitro. J Pharm Pharmacol 53:1069–1077
Trotta M, Peira E, Carlotti ME, Gallarate M (2004) Deformable liposomes for dermal administration of methotrexate. Int J Pharm 270:119–125
Dubey V, Mishra D, Asthana A, Jain NK (2006) Transdermal delivery of a pineal hormone: melatonin via elastic liposomes. Biomaterials 27:3491–3496
Cevc G, Gebauer D, Stieber J, Schätzlein A, Blume G (1998) Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta 1368:201–215
Cevc G, Blume G (2001) New, highly efficient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, Transfersomes. Biochim Biophys Acta 1514:191–205
Gupta PN, Mishra V, Rawat A, Dubey P, Mahor S, Jain S, Chatterji DP, Vyas SP (2005) Non-invasive vaccine delivery in transfersomes, niosomes and liposomes: a comparative study. Int J Pharm 293:73–82
van den Bergh BA, Wertz PW, Junginger HE, Bouwstra JA (2001) Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements. Int J Pharm 217:13–24
Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M (2000) Ethosomes—novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J Control Release 65:403–418
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Yokota, M., Tokudome, Y. (2017). Related Topic: Liposomes—Recent Advances and Future Perspective. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_11
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DOI: https://doi.org/10.1007/978-4-431-56526-0_11
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