Abstract
Many solid transdermal formulations have been developed over the last several decades. These formulations can be classified according to various angles. With respect to water content in the formulation, the non-aqueous solid formulations are called dermal patches or plasters, and the aqueous solid formulations are classified as cataplasms. Similarly, the classification into reservoir type and matrix type can be done from the aspect of patch configuration. This chapter summarizes the various patch formulations already marketed in several countries and provides the basic components and compositions of these formulations.
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Higuchi T (1960) Physical chemical analysis of percutaneous absorption process from creams and ointments. J Cosmet Sci 11(2):85–97
Crank J (1956) Diffusion in a plane sheet. In: The mathematics of diffusion, Chap. 4. Clarendon press, Oxford, pp 44–68
Guy RH et al (1982) A pharmacokinetic model for percutaneous absorption. Int J Pharm 11(2):119–129
Cooper ER, Berner B (1985) Finite dose pharmacokinetics of skin penetration. J Pharm Sci 74(10):1100–1102
Kubota K, Ishizaki T (1986) A calculation of percutaneous drug absorption-I. Theoretical. Comput Biol Med 16(1):7–19
Tojo K (1987) Mathematical modeling of transdermal drug delivery. J Chem Eng Jpn 20(3):300–308
Kubota K, Ishizaki T (1986) A diffusion-diffusion model for percutaneous drug absorption. J Pharmacokinet Biopharm 14(4):409–439
Addicks WJ et al (1989) A mathematical model to describe drug release from thin topical applications. Int J Pharm 56:243–248
Scheuplein RJ (1966) Mechanism of percutaneous absorption. I. Routes of penetration and the influence of solubility. J Invest Dermatol 45:334–346
Stoughton RB (1982) Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one. Arch Dermatol 118(7):474–477
Kanikkannan N et al (2000) Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery. Curr Med Chem 7(6):593–608
Estraderm product label. Revision07/2012
Transiderm-Nitro product label. Revision08/2011
Duragesic product label. Revision2005
Duragesic product label. Revision07/2009
Androderm product label. Revision05/2015
Peterson TA et al (1997) Design, development, manufacturing, and testing of transdermal drug delivery systems. In: Transdermal and topical drug delivery systems. Chapter 8. Interpharm Press, Buffalo Grove, pp 249–297
Chien YW et al (1983) Comparative controlled skin permeation of nitroglycerin from marketed transdermal delivery systems. J Pharm Sci 72(8):968–970
Shaw J (1983) Development of transdermal therapeutic systems. Drug Dev Ind Pharm 9(4):579–603
U.S. Food and Drug Administration (2009) http://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm126727.htm. Accessed 25 Dec 2015
Kandavilli S et al (2002) Polymers in transdermal drug delivery systems. Pharm Tech 26:62–80
Cleary GW (1993) Transdermal delivery systems: a medical rationale. In: Topical drug bioavailability, bioequivalence, and penetration. Chapter 2. Plenum Press, New York and London, pp 17–68
Butrans product label. Revision06/2014
Exelon patch product label. Revision06/2013
Catapres-TTS product label. Revision10/2011
Transderm-Scop product label. Revision04/2013
Kraus G et al (1979) Tack and viscoelasticity of block copolymer based adhesive. J Adhes 10(3):221–236
Dale WC et al (1989) Mechanical properties of acrylic pressure sensitive adhesives and their relationships to industry standard testing. J Adhes 31(1):1–20
Heddleson SS, Pfister WR (1993) The Dahlquist criterion: applicability of a rheological criterion to the loss of pressure-sensitive tack in flour-water dough. Cereal Chem 70(6):744–748
Tan HS et al (1999) Pressure-sensitive adhesives for transdermal drug delivery systems. Pharm Sci Technolo Today 2(2):60–69
Taghizadeh SM et al (2007) The effect of poly(vinylpyrrolidone) concentration on peel strength of acrylic/PVP pressure sensitive adhesive blends. Iran Polym J 16(4):279–285
Kenney JF et al (1992) Medical-grade acrylic adhesives for skin contact. J Appl Polym Sci 45(2):355–361
Dhal PK et al (1982) Pressure sensitive adhesives of acrylic polymers containing functional monomers. Polymer 23:937–939
Cantor AS, Wirtanen DJ (2002) Novel acrylate adhesives for transdermal drug delivery. Pharm Tech 26(1):28–38
Naruse M et al (2012) Development of transdermal therapeutic formulation of CNS5161, a novel n-methyl-d-aspartate receptor antagonist, by utilizing pressure-sensitive adhesives I. Biol Pharm Bull 35(3):321–328
Thomas X. Silicone adhesives in healthcare applications. Dow Corning, Form No. 52-1057-01
Colas A. Silicones in pharmaceutical applications. Dow Corning, Form No. 51-993A-01
U.S. Food and Drug Administration http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm094861.htm. Accessed 25 Dec 2015
Raghavan SL et al (2001) Crystallization of hydrocortisone acetate: influence of polymers. Int J Pharm 212:213–221
Ma X et al (1996) Control of drug crystallization in transdermal matrix system. Int J Pharm 142:115–119
Sinha VR, Kaur MP (2000) Permeation enhancers for transdermal drug delivery. Drug Dev Ind Pharm 26(11):1131–1140
Williams AC, Barry BW (2004) Penetration enhancers. Adv Drug Deliv Rev 56:603–618
Lane ME (2013) Skin penetration enhancers. Int J Pharm 447:12–21
Barry BW (1987) Mode of action of penetration enhancers in human skin. J Control Rel 6:85–97
Narishetty STK, Panchagnula R (2004) Transdermal delivery of zidovudine: effect of terpenes and their mechanism of action. J Control Rel 95:367–379
Ahad A et al (2009) Chemical penetration enhancers: a patent review. Expert Opin Ther Pat 19(7):969–988
Kang L et al (2007) Formulation development of transdermal dosage forms: quantitative structure-activity relationship model for predicting activities of terpenes that enhance drug penetration through human skin. J Control Rel 120(3):211–219
ICH Harmonized Tripartite Guideline (2006) Impurities in new drug products Q3B(R2)
Zhai H, Maibach HI (2001) Effects of skin occlusion on percutaneous absorption: An overview. Skin Pharmacol Appl Skin Physiol 14:1–10
Lidoderm product label. Revision01/2015
Akazawa M (1997) External anti-inflammatory and analgesic plaster preparation. US Patent 5,607,690
Ono M et al (1998) External preparation for application to the skin containing lidocaine. US Patent 5,827,529
Kubo J et al (2014) Lidocaine-containing hydrogel patch. US Patent 8,920,831
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Michinaka, Y. (2017). Dermal Patches, Plasters, and Cataplasms. In: Sugibayashi, K. (eds) Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56526-0_10
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DOI: https://doi.org/10.1007/978-4-431-56526-0_10
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