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Primary Testicular Lymphoma

  • Keisuke SasaiEmail author
Chapter

Abstract

Primary testicular lymphoma (PTL) usually occurs as a diffuse large B-cell lymphoma in elderly males. The first diagnostic and therapeutic procedure in a patient with PTL is inguinal orchiectomy. The guidelines of the International Lymphoma Radiation Oncology Group recommend rituximab combined with CHOP or more aggressive regimens as the first-line systemic treatment, with prophylactic intrathecal or intravenous methotrexate to avoid disease relapse in the CNS, the most common site of tumor recurrence. Because the testis is a sanctuary, the tumor in this organ is not responsive to systemic chemotherapy. The contralateral testis should be irradiated to prevent recurrence.

Keywords

Blood–testicular barrier Prophylaxis of CNS relapse R-CHOP Radiation therapy of the contralateral testis 

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Copyright information

© Springer Japan 2017

Authors and Affiliations

  1. 1.Department of Radiation OncologyJuntendo University, Graduate School of MedicineTokyoJapan

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