Oxidative Stress Regulation by Reactive Cysteine Persulfides in Inflammation
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Reactive oxygen species (ROS) such as superoxide anion radical and hydrogen peroxide are ubiquitously generated during metabolisms of aerobic organisms. Excess production of ROS due to imbalance between formation and removal of ROS by the antioxidant system causes oxidative stress-related tissue damage. Therefore reinforcement of antioxidant capacity has been considered as a beneficial approach for treatment and prevention of chronic inflammatory disorders where ROS production is persistently activated. Cysteine persulfide was recently identified regarding its endogenous formation in mammalian cells. Biochemical analyses revealed that cysteine persulfide and its derivatives such as glutathione persulfide act as a strong antioxidant in cells. Better understanding of the antioxidant actions of cysteine persulfides in chronic inflammation-associated diseases is a necessary basis to develop new strategies for disease treatment and prevention by modulating the process of oxidative stress.
KeywordsReactive oxygen species Oxidative stress Inflammatory mediators Antioxidants Cysteine persulfide Cellular senescence
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