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Bile Acids in Gastroenterology pp 177–184Cite as

Bile Acids and Esophageal Cancer

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Abstract

The incidence rates of esophageal adenocarcinoma and its precursor lesion, Barrett’s esophagus, have increased considerably in Western countries. Duodenogastroesophageal bile reflux is the major cause of this disease. Bile acids induce cytotoxicity in the esophageal epithelium through production of reactive oxygen species and activation of nuclear factor-κB and its downstream signaling pathways. Recent studies have revealed the characteristics of bile acid receptors and transporters in Barrett’s esophagus and esophageal adenocarcinoma.

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Author information

Authors and Affiliations

  1. Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Juntaro Matsuzaki

  2. Medical Education Center, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Hidekazu Suzuki

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  1. Juntaro Matsuzaki
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  2. Hidekazu Suzuki
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Correspondence to Hidekazu Suzuki .

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Editors and Affiliations

  1. Department of General Medicine, Hiroshima University Hospital, Hiroshima, Japan

    Susumu Tazuma

  2. Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan

    Hajime Takikawa

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© 2017 Springer Japan KK

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Matsuzaki, J., Suzuki, H. (2017). Bile Acids and Esophageal Cancer. In: Tazuma, S., Takikawa, H. (eds) Bile Acids in Gastroenterology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56062-3_13

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  • DOI: https://doi.org/10.1007/978-4-431-56062-3_13

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-56060-9

  • Online ISBN: 978-4-431-56062-3

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