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Mesenchymal Stem Cells

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Cell Therapy Against Cerebral Stroke

Abstract

Mesenchymal stem cells (MSCs) derived from adult human bone marrow hold a spectrum of functional properties. Intravenous infusion of MSCs provides functional improvements in animal models including cerebral stroke and spinal cord injury. Suggested mechanisms may include neuroprotection, angiogenesis, induction of axonal sprouting, and remyelination.

Therapeutic effects have been reported in animal models of stroke after intravenous infusion of human MSCs derived from adult human bone marrow. Initial clinical studies on intravenously infused MSCs have now been completed in human stroke patients. Here, we review the reparative and protective properties of infused MSCs in stroke models, describe initial human studies on intravenous infusion of MSC in stroke, and provide a perspective on prospects for future progress with MSCs.

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Author information

Authors and Affiliations

  1. Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan

    Masanori Sasaki M.D., Ph.D. & Osamu Honmou M.D., Ph.D.

Authors
  1. Masanori Sasaki M.D., Ph.D.
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  2. Osamu Honmou M.D., Ph.D.
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Corresponding author

Correspondence to Masanori Sasaki M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Hokkaido University Graduate School of M, Department of Neurosurgery, Sapporo, Hokkaido, Japan

    Kiyohiro Houkin

  2. Okayama University Graduate School of Me, Department of Neurology, Okayama, Okayama, Japan

    Koji Abe

  3. Graduate School of Medicine and Pharmace, Department of Neurosurgery, Toyama, Toyama, Japan

    Satoshi Kuroda

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© 2017 Springer Japan KK

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Sasaki, M., Honmou, O. (2017). Mesenchymal Stem Cells. In: Houkin, K., Abe, K., Kuroda, S. (eds) Cell Therapy Against Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56059-3_12

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  • DOI: https://doi.org/10.1007/978-4-431-56059-3_12

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-56057-9

  • Online ISBN: 978-4-431-56059-3

  • eBook Packages: MedicineMedicine (R0)

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