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Activity Dependent Protein Transport from the Synapse to the Nucleus

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Abstract

It is widely accepted that signaling between synapses and neuronal nuclei regulates activity-dependent gene transcription that plays a crucial role in synaptic plasticity. However, despite many years of research, it is still essentially unclear how signals from distal synapses are transduced to the nucleus. Several studies in the past decade have proposed mechanisms of activity-dependent transport of synaptic proteins to the nucleus. In this chapter we will discuss these mechanisms and how this transport might couple in particular NMDAR activation to specific aspects of gene transcription.

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Authors and Affiliations

  1. RG Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestr 6, 39118, Magdeburg, Germany

    Sujoy Bera, Gonca Bayraktar, Katarzyna M. Grochowska, Michelle Melgarejo da Rosa & Michael R. Kreutz

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  1. Sujoy Bera
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  2. Gonca Bayraktar
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  3. Katarzyna M. Grochowska
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  4. Michelle Melgarejo da Rosa
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  5. Michael R. Kreutz
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Correspondence to Michael R. Kreutz .

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Editors and Affiliations

  1. Graduate School of Science, The University of Tokyo, Tokyo, Japan

    Kazuo Emoto

  2. Department of Biological Structure, University of Washington, Seattle, Washington, USA

    Rachel Wong

  3. Department of Pathology, University of California San Francisco, San Francisco, California, USA

    Eric Huang

  4. Faculty of Science, Utrecht University, Utrecht, The Netherlands

    Casper Hoogenraad

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Bera, S., Bayraktar, G., Grochowska, K.M., da Rosa, M.M., Kreutz, M.R. (2016). Activity Dependent Protein Transport from the Synapse to the Nucleus. In: Emoto, K., Wong, R., Huang, E., Hoogenraad, C. (eds) Dendrites. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56050-0_5

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