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Mechanism of Action of Immunoglobulin: Sialylated IgG

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Kawasaki Disease

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Abstract

Glycosylation of IgG, including sialylation of the Fc region, influences binding of IgG to receptors. In addition to the classical Fc receptor members, we now know of several sugar-binding lectins that recognize sialylated oligosaccharides of IgG. These lectins, particularly human dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), may regulate immune reactions and are thus candidate molecules in the initiation of the sequence of IVIG-mediated anti-inflammatory events. This chapter reviews the emerging role of sialylated IgG Fc in the IVIG-mediated therapeutic effect, in particular the importance of DC-SIGN-initiated events.

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Acknowledgements

The author thanks Nicholas Halewood for editorial assistance. This work is supported in part by a Grant-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (to TT).

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Authors and Affiliations

  1. Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai, 980-8575, Japan

    Toshiyuki Takai

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  1. Toshiyuki Takai
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Correspondence to Toshiyuki Takai .

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Editors and Affiliations

  1. Advanced and Integrated Cardiovascular Research Course in the Young and Adolescence, Toho University, Tokyo, Japan

    Ben Tsutomu Saji

  2. Boston Children’s Hospital, Harvard Medical School, Department of Cardiology, Boston, Massachusetts, USA

    Jane W. Newburger

  3. Department of Pediatrics, Rady Children’s Hospital, University of California San Diego School of Medicine, La Jolla, USA

    Jane C. Burns

  4. Heart Center , Seattle Childrens Hospital, Seattle, USA

    Masato Takahashi

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© 2017 Springer Japan

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Takai, T. (2017). Mechanism of Action of Immunoglobulin: Sialylated IgG. In: Saji, B., Newburger, J., Burns, J., Takahashi, M. (eds) Kawasaki Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-56039-5_25

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  • DOI: https://doi.org/10.1007/978-4-431-56039-5_25

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-56037-1

  • Online ISBN: 978-4-431-56039-5

  • eBook Packages: MedicineMedicine (R0)

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