Advertisement

Ovarian Tissue Freezing and Transplantation: Current Status

  • Jacques DonnezEmail author
  • Marie-Madeleine Dolmans
Chapter
  • 591 Downloads

Abstract

Purpose of Review

To carefully evaluate a number of critical points related to ovarian tissue freezing and present factual data in terms of live birth rates and risks.

Recent Findings

Reimplantation of frozen-thawed ovarian tissue remains an experimental procedure according to the ASRM, despite more than 40 live births reported in the literature.

Summary

This manuscript emphasizes the crucial importance of not only pre serving fertility in young women, but also clearly explaining to patients the different available options and their respective success rates.

Some previously published reviews have reported inaccurate reimplantation success rates. In this review, we report the true picture, with a live birth rate of 25 %.

Ovarian tissue freezing may be combined with pickup of immature oocytes (at the time of ovarian biopsy and tissue removal) or mature oocytes (if chemotherapy can be delayed).

Keywords

Ovary Ovarian tissue cryopreservation Freezing Reimplantation 

References

  1. 1.
    Donnez J, Martinez-Madrid B, Jadoul P et al (2006) Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update 12:519–535CrossRefPubMedGoogle Scholar
  2. 2.
    Donnez J, Dolmans MM (2013) Fertility preservation in women. Nat Rev Endocrinol 9:735–749CrossRefPubMedGoogle Scholar
  3. 3.
    Donnez J, Dolmans MM (2014) Transplantation of ovarian tissue. Best Pract Res Clin Obstet Gynaecol 28:1188–1197CrossRefPubMedGoogle Scholar
  4. 4.
    Wallace WH, Thomson AB, Kelsey TW (2003) The radiosensitivity of the human oocyte. Hum Reprod 18:117–121CrossRefPubMedGoogle Scholar
  5. 5.
    Wallace WHB, Anderson RA, Irvine DS (2005) Fertility preservation for young patients with cancer: who is at risk and what can be offered? Lancet Oncol 6:209–219CrossRefPubMedGoogle Scholar
  6. 6.
    Meirow D, Nugent D (2001) The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update 7:535–543CrossRefPubMedGoogle Scholar
  7. 7.
    Donnez J, Dolmans MM, Demylle D et al (2006) Restoration of ovarian function after orthotopic (intraovarian and periovarian) transplantation of cryopreserved ovarian tissue in a woman treated by bone marrow transplantation for sickle cell anemia: case report. Hum Reprod 21:183–188CrossRefPubMedGoogle Scholar
  8. 8.
    Wallace WH, Thomson AB, Saran F, Kelsey TW (2005) Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys 62:738–744CrossRefPubMedGoogle Scholar
  9. 9.
    Jadoul P, Donnez J (2012) How does bone marrow transplantation affect ovarian function and fertility? Curr Opin Obstet Gynecol 24:164–171CrossRefPubMedGoogle Scholar
  10. 10.
    Jadoul P, Dolmans MM, Donnez J (2010) Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update 16:617–630CrossRefPubMedGoogle Scholar
  11. 11.
    Wallace WH, Smith AG, Kelsey TW et al (2014) Fertility preservation for girls and young women with cancer: population-based validation of criteria for ovarian tissue cryopreservation. Lancet Oncol 15:1129–1136CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Teinturier C, Hartmann O, Valteau-Couanet D et al (1998) Ovarian function after autologous bone marrow transplantation in childhood: high-dose busulfan is a major cause of ovarian failure. Bone Marrow Transplant 22:989–994CrossRefPubMedGoogle Scholar
  13. 13.
    Bedoschi G, Oktay K (2013) Current approach to fertility preservation by embryo cryopreservation. Fertil Steril 99:1496–1502CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Cobo A, Garcia-Velasco JA, Domingo J et al (2013) Is vitrification of oocytes useful for fertility preservation for age-related fertility decline and in cancer patients? Fertil Steril 99:1485–1495CrossRefPubMedGoogle Scholar
  15. 15.
    Cakmak H, Rosen MP (2013) Ovarian stimulation in cancer patients. Fertil Steril 99:1476–1484CrossRefPubMedGoogle Scholar
  16. 16.
    Andersen CY, Rosendahl M, Byskov AG et al (2008) Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod 23:2266–2272CrossRefPubMedGoogle Scholar
  17. 17.
    Donnez J, Jadoul P, Pirard C et al (2012) Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease. Fertil Steril 98:720–725CrossRefPubMedGoogle Scholar
  18. 18.
    Oktay K, Economos K, Kan M et al (2001) Endocrine function and oocyte retrieval after autologous transplantation of ovarian cortical strips to the forearm. JAMA 26:1490–1493CrossRefGoogle Scholar
  19. 19.
    Kim SS (2012) Assessment of long term endocrine function after transplantation of frozen-thawed human ovarian tissue to the heterotopic site: 10 year longitudinal follow-up study. J Assist Reprod Genet 29:489–493CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Stern CJ, Gook D, Hale LG et al (2013) First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy. Hum Reprod 28:2996–2999CrossRefPubMedGoogle Scholar
  21. 21.
    Stoop D, Cobo A, Silber S (2014) Fertility preservation for age-related fertility decline. Lancet 384(9950):1311–1319CrossRefPubMedGoogle Scholar
  22. 22.
    Donnez J, Dolmans MM, Pellicer A et al (2015) Fertility preservation for age-related fertility decline. Lancet Letter to the Editor 385(9967):506–507Google Scholar
  23. 23.
    Rodriguez-Wallberg KA, Karlström PO et al (2015) Full-term newborn after repeated ovarian tissue transplants in a patient treated for Ewing sarcoma by sterilizing pelvic irradiation and chemotherapy. Acta Obstet Gynecol Scand 94(3):324–328CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Suzuki N, Yoshioka N, Takae S, Sugishita Y, Tamura M, Hashimoto S, Morimoto Y, Kawamura K (2015) Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency. Hum Reprod 30(3):608–615CrossRefPubMedGoogle Scholar
  25. 25.
    Burmeister L, Kovacs GT, Osianlis T (2013) First Australian pregnancy after ovarian tissue cryopreservation and subsequent autotransplantation. Med J Aust 198(3):158–159CrossRefPubMedGoogle Scholar
  26. 26.
    Donnez J, Dolmans MM (2015) Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J Assist Reprod Genet 32(8):1167–1170CrossRefPubMedGoogle Scholar
  27. 27.
    Dittrich R, Hackl J, Lotz L et al (2015) Pregnancies and live births after 20 transplantations of cryopreserved ovarian tissue in a single center. Fertil Steril 103(2):462–468. doi: 10.1016/j.fertnstert.2014.10.045 CrossRefPubMedGoogle Scholar
  28. 28.
    Donnez J, Dolmans MM, Diaz C, Pellicer A (2015) Ovarian cortex transplantation: time to move on from experimental studies to open clinical application. Fertil Steril 104(5):1097–1098CrossRefPubMedGoogle Scholar
  29. 29.
    Fasano G, Moffa F, Dechène J et al (2011) Vitrification of in vitro matured oocytes collected from antral follicles at the time of ovarian tissue cryopreservation. Reprod Biol Endocrinol 9:150CrossRefPubMedPubMedCentralGoogle Scholar
  30. 30.
    Prasath EB, Chan ML, Wong WH et al (2014) First pregnancy and live birth resulting from cryopreserved embryos obtained from in vitro matured oocytes after oophorectomy in an ovarian cancer patient. Hum Reprod 29:276–278CrossRefPubMedGoogle Scholar
  31. 31.
    Segers I, Mateizel I, Guzman L, et al (2015) In vitro maturation of ex vivo harvested oocytes obtained after ovariectomy: a promising additional source of gamete preservation leading to the first clinical pregnancy in UZ Brussel. In: Proceedings of the Congress “Freezing of oocytes, embryos and ovarian tissue: focus on fertility management and fertility preservation. Brussels, 16–17 January 2015. JARG, submittedGoogle Scholar
  32. 32.
    Dolmans MM, Marotta ML, Pirard C et al (2014) Ovarian tissue cryopreservation followed by controlled ovarian stimulation and pick-up of mature oocytes does not impair the number or quality of retrieved oocytes. J Ovarian Res 7:80CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Dolmans MM, Donnez J, Camboni A et al (2009) IVF outcome in patients with orthotopically transplanted ovarian tissue. Hum Reprod 24:2778–2787CrossRefPubMedGoogle Scholar
  34. 34.
    Nottola SA, Camboni A, Van Langendonckt A et al (2008) Cryopreservation and xenotransplantation of human ovarian tissue: an ultrastructural study. Fertil Steril 90:23–32CrossRefPubMedGoogle Scholar
  35. 35.
    Van Eyck AS, Jordan BF, Gallez B et al (2009) Electron paramagnetic resonance as a tool to evaluate human ovarian tissue reoxygenation after xenografting. Fertil Steril 92:374–381CrossRefPubMedGoogle Scholar
  36. 36.
    Dolmans MM, Martinez-Madrid B, Gadisseux E et al (2007) Short-term transplantation of isolated human ovarian follicles and cortical tissue into nude mice. Reproduction 134:253–262CrossRefPubMedGoogle Scholar
  37. 37.
    David A, Van Langendonckt A, Gilliaux S et al (2012) Effect of cryopreservation and transplantation on the expression of kit ligand and anti-Müllerian hormone in human ovarian tissue. Hum Reprod 27:1088–1095CrossRefPubMedGoogle Scholar
  38. 38.
    Labied S, Delforge Y, Munaut C et al (2013) Isoform 111 of vascular endothelial growth factor (VEGF111) improves angiogenesis of ovarian tissue xenotransplantation. Transplantation 95:426–433CrossRefPubMedGoogle Scholar
  39. 39.
    Dath C, Dethy A, Van Langendonckt A et al (2011) Endothelial cells are essential for ovarian stromal tissue restructuring after xenotransplantation of isolated ovarian stromal cells. Hum Reprod 26:1431–1439CrossRefPubMedGoogle Scholar

Copyright information

© Springer Japan 2016

Authors and Affiliations

  1. 1.Infertility Research UnitSociété de Recherche pour l’Infertilité (SRI)BrusselsBelgium
  2. 2.Gynecology Research Unit, Institut de Recherche Expérimentale et CliniqueUniversité Catholique de LouvainBrusselsBelgium

Personalised recommendations