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History and Latest Concepts of Lewy Body Disease and Dementia with Lewy Bodies

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Dementia with Lewy Bodies

Abstract

We proposed the term “Lewy body disease” (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type, and a diffuse type. Later, we added the cerebral type. As we have proposed since 1980, LBD has recently been used as a generic term including Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB).

LBD has neuropathological characteristics whereby numerous Lewy bodies are present in the central and sympathetic nervous systems, and it is a type of alpha-synucleinopathy because the main component of Lewy body is alpha-synuclein. On the other hand, the nomenclature of DLB was proposed at the first International Workshop, which was held in Newcastle upon Tyne (England) in 1995. The result of the Workshop was published in Neurology in 1996. DLB is now called the second most frequent dementia, following Alzheimer’s disease (AD). In this chapter, the author explains the most recent concept of LBD and DLB from the historical viewpoint.

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Authors and Affiliations

  1. Department of Psychiatry, Yokohama City University School of Medicine, 65 Fukuura, Kanazawa-ku, Yokohama, 256-0002, Japan

    Kenji Kosaka

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Correspondence to Kenji Kosaka .

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  1. Yokohama City University, Yokohama, Kanagawa, Japan

    Kenji Kosaka

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Kosaka, K. (2017). History and Latest Concepts of Lewy Body Disease and Dementia with Lewy Bodies. In: Kosaka, K. (eds) Dementia with Lewy Bodies. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55948-1_1

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  • DOI: https://doi.org/10.1007/978-4-431-55948-1_1

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