Future Developments

  • Toshimitsu Hamasaki
  • Koko Asakura
  • Scott R. Evans
  • Toshimitsu Ochiai
Chapter
Part of the SpringerBriefs in Statistics book series (BRIEFSSTATIST)

Abstract

Chapters  1 6 focus on selected emerging statistical issues in clinical trials. This work provides a foundation for designing randomized trials with other design features. This includes clinical trials with more than two interventions (e.g., dose-selection clinical trials): trials with time-to-event endpoints and trials with targeted subgroups and enrichment clinical trial designs. In Chap.  7, we briefly discuss the issues in the design of these trials.

Keywords

Endpoint selection Enrichment clinical trial designs Multiple-arm Subgroup analysis Time-to-event outcomes 

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Copyright information

© The Author(s) 2016

Authors and Affiliations

  • Toshimitsu Hamasaki
    • 1
  • Koko Asakura
    • 2
  • Scott R. Evans
    • 3
  • Toshimitsu Ochiai
    • 4
  1. 1.Department of Data ScienceNational Cerebral and Cardiovascular CenterSuitaJapan
  2. 2.Department of Data ScienceNational Cerebral and Cardiovascular CenterSuitaJapan
  3. 3.Department of Biostatistics and the Center for Biostatistics in AIDS ResearchHarvard T.H. Chan School of Public HealthBostonUSA
  4. 4.Biostatistics DepartmentShionogi & Co., Ltd.OsakaJapan

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