Aging-Related Neurodegenerative Diseases in Caenorhabditis elegans
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are aging-dependent. As aged population grows, neurodegenerative diseases have become the major threats to human health and serious social burdens worldwide. Recently, research in neurodegenerative diseases has entered the Renaissance age, as several genes responsible for the diseases were identified. In this chapter, we explain why Caenorhabditis elegans (C. elegans) is an excellent animal model for the studies on neurodegenerative diseases and describe how this animal model has contributed to understanding of the mechanism of the diseases. Several features of C. elegans make it a particularly useful model for searching for genetic modifiers of disease phenotypes and for investigating the role of aging in disease development and progression.
KeywordsNeurodegenerative diseases Caenorhabditis elegans Aging Protein aggregation Alzheimer’s disease Parkinson’s disease Huntington’s disease Amyotrophic lateral sclerosis
This work was supported by the National Research Foundation (NRF) grant funded by the Korean Government (MEST) (No. 2010-0015188), and the Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C0093).
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