Centenarian Studies: An Interdisciplinary Research on Healthy Longevity
The scope and purpose of this chapter is to summarize aims, methods, and findings of centenarian studies, mainly from our own as an interdisciplinary research. Although most of centenarians remain independent in daily living until over 90s, about 97 % of them contracted chronic diseases including hypertension (63.6 %) and bone fracture (46.4 %). The prevalence of diabetes mellitus (DM) and carotid atherosclerotic plaque were peculiarities of centenarians, which could be associated with high adiponectin levels. While conducting the Tokyo centenarian study (TCS), we found that only 20 % of them enjoyed physical and cognitive independence at the age of 100 years, this elite subpopulation were highly likely to become semisupercentenarians (over 105 years) or even supercentenarians (beyond 110 years). Therefore, we began to think that 100 years of age is not a model of longevity, but over 105 years is. We describe the preliminary results of the Japan Semisupercentenarian Study which led to our conviction that semi-supercentenarians are a more appropriate model for the study of human longevity.
KeywordsCentenarian Supercentenarian Healthy longevity Physical function Inflammation Adipose tissue Personality
We sincerely appreciate centenarians , their family and care-givers. The data presented in this chapter owed their kind and willing corporation. We also express sincere gratitude to Ms. Yukiko Abe and Ms. Miho Shimura for their arrangement of field works.
- Demographic Trends in Japan and World (2005) Tokyo: National Institute of Population and Social Security Research, Health and Welfare Statistics AssociationGoogle Scholar
- Abott A (2004) Ageing: growing old gracefully. Nature 428:116–118Google Scholar
- Costa PTJ, McCrae RR (1985) The NEO personality inventory manual. Psychological Assessment Resources, LutzGoogle Scholar
- Franchschi C, Bonafe M, Valensin S et al (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Molecular and cellular gerontology (Toussaint O, Osiewacz HD, Lithgow GJ, Brack C eds). Ann N Y Acad Sci 908: 244–254.Google Scholar
- Hirose N, Arai Y, Gondo Y et al (2004) Tokyo centenarian study: aging inflammation hypothesis. GGI 4:S182–S185Google Scholar
- Scoub WW (1994) Cytokine control of nutrition and metabolism in critical illness. Curr Probl Surg 340:448–454Google Scholar
- Stefan N, Vozarova B, Funahashi T et al (2002) Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes 51:1884–1888CrossRefPubMedGoogle Scholar