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Role of the Forkhead Box O Family and Neuropeptide Y in Calorie Restriction

  • Ryoichi Mori
  • Seongjoon Park
  • Isao ShimokawaEmail author

Abstract

Calorie restriction (CR) is known to extend lifespan and reduce the risk of various morbidities in lower animals to primates. The effects of CR are regulated by the expression of several age-related genes and a signaling pathway, including forkhead box O (FOXO) and neuropeptide Y (NPY). Heterozygous Foxo1-deficient mice under CR exhibit alterations in cancer development but not lifespan, indicating that FOXO1 contributes to anti-cancer effects in aging. NPY deficiency in mice under CR attenuates lifespan and adiposity but does not affect anticancer efficacy and oxidant stress tolerance, suggesting that NPY might play a role in the regulation of age-related metabolic diseases. Furthermore, intracellular organelles including mitochondria contribute to CR benefits. Recently, CR effects have been examined in individuals, leading to development of CR mimetic compounds. This review summarizes the current insights into the molecular mechanisms linking regulation of age-related genes and CR benefits in mammals.

Keywords

Calorie restriction Calorie restrictionmimetics Longevity FOXO NPY 

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Copyright information

© Springer Japan 2015

Authors and Affiliations

  1. 1.Department of Pathology, Graduate School of Biomedical SciencesNagasaki UniversityNagasakiJapan

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