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Protein Modifications Pace the Circadian Oscillation of Biological Clocks

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Protein Modifications in Pathogenic Dysregulation of Signaling

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Abstract

In modern societies, many people have trouble with their sleep, mental health, and metabolic status, which show daily rhythms. The daily rhythms are also observed in the risk of diseases such as cardiovascular disease, allergic reaction, and asthma. Increasingly, studies report time-of-the-day-dependent changes in both the medicinal benefits of drugs and their undesirable side effects. Search of the best daily timing for such drug administration is very important, being emphasized as chronopharmacology or chronotherapy. These rhythms in the benefits and the risks are based on the circadian clockwork that is generated by transcriptional–translational negative feedback loops of the so-called clock genes. The time measuring system absolutely requires post-translational modifications of the clock gene products, that is, clock proteins. Clock protein modifications control many aspects of the circadian clock such as stability, cellular localization profiles, transcriptional activity, and protein–protein interactions. In this chapter, we present an overview of recent molecular and genetic studies by focusing on a series of the post-translational modifications of clock proteins.

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Authors and Affiliations

  1. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-0033, Japan

    Hikari Yoshitane & Yoshitaka Fukada

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  1. Hikari Yoshitane
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  2. Yoshitaka Fukada
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Correspondence to Yoshitaka Fukada .

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  1. Division of Cellular & Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

    Jun-ichiro Inoue

  2. The Institute of Medical Science Division of Cell Signaling & Molecular Medicine, The University of Tokyo, Tokyo, Japan

    Mutsuhiro Takekawa

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Yoshitane, H., Fukada, Y. (2015). Protein Modifications Pace the Circadian Oscillation of Biological Clocks. In: Inoue, Ji., Takekawa, M. (eds) Protein Modifications in Pathogenic Dysregulation of Signaling. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55561-2_16

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