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Indocyanine Green-Related Transporters in Hepatocellular Carcinoma

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Abstract

Intraoperative indocyanine green (ICG) fluorescent imaging under near-infrared light is a useful procedure to detect hepatocellular carcinoma (HCC). However, the mechanisms of ICG accumulation in HCC have been unclear. We hypothesized that some transporters on the hepatocytes may be involved in the process of ICG accumulation and examined the expression levels of influx and efflux transporters using resected HCC tissues. Among influx transporter, organic anion-transporting polypeptide 1B3 (OATP1B3) and sodium-taurocholate transport protein (NTCP) are suggested to be responsible for ICG export in HCC. Interestingly, multidrug resistance p-glycoprotein-3 (MDR3), an efflux transporter to canaliculi, is also one of the important ICG transporters and a prognostic factor of HCC. We speculated that ICG is uptaken into hepatocytes through OATP1B3 and accumulated into the blunt-end pseudo-glands or bile canaliculi in HCC tissues through the efflux by MDR3.

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Authors and Affiliations

  1. Second Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan

    Yasushi Shibasaki, Y. Morita, T. Sakaguchi & H. Konno

Authors
  1. Yasushi Shibasaki
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  2. Y. Morita
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  3. T. Sakaguchi
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  4. H. Konno
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Corresponding author

Correspondence to Yasushi Shibasaki .

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Editors and Affiliations

  1. Department of Surgery, Seiwa Memorial Hospital, Sapporo, Hokkaido, Japan

    Mitsuo Kusano

  2. Hepato-Biliary-Pancreatic Surgery Divisi, University of Tokyo, TOKYO 113-8655, Tokyo, Japan

    Norihiro Kokudo

  3. Department of Breast Surgery Graduate Sc, Kyoto University, Kyoto, Kyoto, Japan

    Masakazu Toi

  4. Department of Surgery, Hirakata Hospital, Kansai Medical University, Hirakata, Osaka, Japan

    Masaki Kaibori

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Shibasaki, Y., Morita, Y., Sakaguchi, T., Konno, H. (2016). Indocyanine Green-Related Transporters in Hepatocellular Carcinoma. In: Kusano, M., Kokudo, N., Toi, M., Kaibori, M. (eds) ICG Fluorescence Imaging and Navigation Surgery. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55528-5_32

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  • DOI: https://doi.org/10.1007/978-4-431-55528-5_32

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55527-8

  • Online ISBN: 978-4-431-55528-5

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