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Oropharyngeal Cancer

  • Chapter
Intensity-Modulated Radiation Therapy

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Abstract

Oropharyngeal cancer accounts for over half of all head and neck cancers in Western countries. The incidence of this cancer has gradually increased and has been associated with HPV infection. The prognosis of patients with HPV-related oropharyngeal cancer is known to be good; therefore, radiotherapy is the preferred treatment due to its functional and cosmetic advantages. Oropharyngeal cancer is considered a good candidate for IMRT because of the clear advantage in reducing late toxicity, especially for xerostomia. The treatment of oropharyngeal cancer is very complicated and requires a multidisciplinary team board. All clinical findings, such as inspection, palpitation, and diagnostic images, are extremely important to accurately assess tumor extension. The early detection of this cancer is expected to have a high cure rate, and adequate CTV contouring is of significance in the planning of IMRT. Advanced stages of the disease require more intensive treatment strategies including chemotherapy and surgery, and IMRT also plays an important role in minimizing adverse events. Recently acquired evidence from prospective trials on oropharyngeal cancer has been highlighted in this chapter, and its perspective is also discussed.

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Acknowledgments

This study was supported in part by a Grant-in-Aid for Cancer Research (H23-009) from the Ministry of Health, Labour and Welfare of Japan.

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Authors and Affiliations

  1. Department of Radiation Oncology, Aichi Cancer Center Hospital, 1-1 Kanoko-den, Chikusa-ku, Nagoya, Aichi, 464-8681, Japan

    Takeshi Kodaira, Arisa Shimizu & Keiichi Takehana

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  1. Takeshi Kodaira
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  2. Arisa Shimizu
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  3. Keiichi Takehana
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Correspondence to Takeshi Kodaira .

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Editors and Affiliations

  1. Department of Radiation Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan

    Yasumasa Nishimura

  2. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Ritsuko Komaki

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Kodaira, T., Shimizu, A., Takehana, K. (2015). Oropharyngeal Cancer. In: Nishimura, Y., Komaki, R. (eds) Intensity-Modulated Radiation Therapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55486-8_9

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  • DOI: https://doi.org/10.1007/978-4-431-55486-8_9

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