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Sequelae of Therapy of Head and Neck Cancer: Their Prevention and Therapy

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Intensity-Modulated Radiation Therapy

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Abstract

Intensity-modulated radiotherapy (IMRT) has an integral part in the management of head and neck cancer (HNC). The head and neck is a compact space with many organs at risk in very close vicinity of the irradiated volumes. This chapter discusses the toxicities associated with therapy of HNC and methods to reduce them, emphasizing the role of IMRT. The main discussed toxicities are xerostomia, dysphagia, hearing loss, speech changes, spinal cord, optic neuropathy, brachial plexopathy, and osteoradionecrosis. The prevalence of these toxicities, their assessment, and dose–effect relationships and methods to prevent and treat them are described.

This chapter emphasizes the role of IMRT in reducing complications of irradiation of head and neck cancer.

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Authors and Affiliations

  1. Department of Radiotherapy, Victoria Hospital, Bangalore Medical College and Research Institute, Fort, K R road, Bangalore, 560002, Karnataka, India

    Amrut S. Kadam M.D.

  2. Department of Radiation Oncology, University of Michigan Hospital, 1500 E Medical Center Drive, UHB2C490, Ann Arbor, MI, 48109, USA

    Avraham Eisbruch M.D.

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  1. Amrut S. Kadam M.D.
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Correspondence to Avraham Eisbruch M.D. .

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  1. Department of Radiation Oncology, Kinki University Faculty of Medicine, Osaka-Sayama, Osaka, Japan

    Yasumasa Nishimura

  2. Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Ritsuko Komaki

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Kadam, A.S., Eisbruch, A. (2015). Sequelae of Therapy of Head and Neck Cancer: Their Prevention and Therapy. In: Nishimura, Y., Komaki, R. (eds) Intensity-Modulated Radiation Therapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55486-8_11

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