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Four-Dimensional Analysis for a Tumor Invasion

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Hyper Bio Assembler for 3D Cellular Systems

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Abstract

Four-dimensional analysis provides the understandings for a tumor invasion. The analysis is of three-dimensional with times. In this part, we describe the cellular mobility focused on reactive oxygen species from mitochondria. Mitochondrial ROS is involved in cancer properties such as growth, metastasis and invasion. On the other hand, carcinogenesis and malignancy are involved in environmental factors such as foods. Thus, we evaluated whether sodium chloride and ethanol induce mitochondrial ROS or not. These results indicated that mitochondrial ROS enhances cancer cellular invasion, meanwhile, sodium chloride and ethanol induced a production of mitochondrial ROS in cells. Taking these results into accounts, sodium chloride and ethanol probably enhances tumor invasion. In addition, cellular morphology is alternated when cells invades into pericellular matrix. If cellular characters such as an ability of invasion can be suggested by cellular observation, classification of cancer cellular malignancy is easy. Therefore, we have developing a novel method of cell picking from three-dimensional culture.

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Authors and Affiliations

  1. Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Masato Tamura & Hirofumi Matsui

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  1. Masato Tamura
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  2. Hirofumi Matsui
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Correspondence to Hirofumi Matsui .

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Editors and Affiliations

  1. Department of Systems Innovation, Osaka University, Toyonaka, Japan

    Tatsuo Arai

  2. Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan

    Fumihito Arai

  3. Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan

    Masayuki Yamato

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Tamura, M., Matsui, H. (2015). Four-Dimensional Analysis for a Tumor Invasion. In: Arai, T., Arai, F., Yamato, M. (eds) Hyper Bio Assembler for 3D Cellular Systems. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55297-0_20

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  • DOI: https://doi.org/10.1007/978-4-431-55297-0_20

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