Updates in Treatment Modalities and Techniques on Compromised Alveolar Ridge Augmentation for Successful Dental Implant Therapy
Installation of dental implants is often hindered by compromised alveolar ridge which requires augmentation. Several methods including autogenous bone graft, guided bone regeneration, and distraction osteogenesis are implied to restore the compromised alveolar ridge. This chapter reviews treatment modalities and techniques of alveolar ridge augmentation. Recent development and updates in this field are also presented.
KeywordsAlveolar ridge augmentation Autogenous block bone grafting Bone graft material Distraction osteogenesis
2.1 Treatment Modalities for Augmentation of the Compromised Alveolar Ridge
Edentulism often exists with concomitant alveolar ridge resorption. Consequently implant installation is very often complicated with severely atrophic alveolar ridge. Various efforts have been tried to overcome the problem of insufficient alveolar bone for ideal implant installation. Alveolar bone augmentation which restores the atrophic alveolar bone to its near intact state will exhibit ideal properties in both functional and esthetic means for implant installation.
Bone restoration capability differs according to the method applied. Guided bone regeneration is restricted in terms of small feasible bone regain amount. When applied with resorbable membranes, the expected bone regeneration does not exceed 3–4 mm vertically and 4 mm horizontally. Titanium mesh may enhance the capability to 4–7 mm vertically and 5 mm horizontally. Onlay block bone graft has similar capability with the latter of GBR technique. Interpositional bone graft is capable of regaining 5–7 mm of vertical height. Distraction osteogenesis is the most capable modality in terms of feasible bone regain amount which may exceed 10 mm in vertical height and 6 mm in alveolar width.
2.2 Autogenous Block Bone Grafting
Autogenous bone graft had been the gold standard of bone grafting. It is the only graft material that is considered to have osteoconductive, osteoinductive, and osteogenetic properties all together. Furthermore when block bone is adapted properly, it may contribute to initial stability of the implant fixture installed simultaneously. This characteristic can increase the feasibility of simultaneous bone grafting and implant installation.
2.2.1 Autogenous Bone Donor Sites
Extraoral donor sites include the anterior iliac crest bone, the proximal tibia bone, and the calvarial bone. These sites may suffice any amount of requisite for an alveolar augmentation.
2.2.2 Block Bone Grafting Techniques
Vertical interpositional bone graft is an alternative to the conventional methods described above, when the bone demand is large. This method has the advantage of preserving the alveolar crest with intact nourished bone. Soft tissue management and flap design is very important and should be done carefully with interpositional bone graft procedures for preserving the vascularity.
2.2.3 The Fate of Autogenous Onlay Bone Graft
Resorption of grafted autogenous bone is always a matter of concern. Cordaro et al. reported that when block bones harvested from the mandibular ramus or symphysis are grafted in an onlay style, mean resorption rates during a graft healing period of 6 months were 23.5 % for lateral grafts and 42 % for verticals . Proussaefs et al. suggested that vertical augmentation of the alveolar ridge with autogenous block bone from the mandibular ramus is a viable treatment option. They reported a vertical resorption rate of 16.34 % from an initial 6.12 mm of augmentation after 4–6 months of healing period . Widmark et al. demonstrated that the horizontal resorption was 25 % after 4 months and 60 % at the time of abutment connection when symphyseal block bone was grafted to the anterior maxilla for single tooth implant installation .
In a clinical survey conducted in our department, 76 patients underwent simultaneous autogenous onlay bone graft and installation of total 256 dental implants from 2000 to 2006. The amount of bone augmentation was 5.42 mm in average. After a minimum follow up period of 2 years, average bone resorption at the mesial and distal site of implant collar was 1.48 mm. About 27.3 % of the augmented bone height was resorbed.
2.2.4 Drawbacks of Autogenous Bone Grafting
Although the autogenous bone is considered as the gold standard of bone grafting for its osteogenic potential, drawbacks exist which limits its application. Donor site morbidity is of the most concern. Bone harvesting procedures may put adjacent anatomical structures at a risk of damage. For instance during chin bone harvesting, the mental nerve may be pulled under undue traction and the incisive nerve may become interrupted when the harvesting depth is inordinate. Ramal bone harvesting can damage the inferior alveolar nerve.
In addition some patients may be reluctant to the harvesting procedures, especially when extraoral donor sites are concerned. General anesthesia is mandatory for these procedures. Gate problem could occur when autogenous bone is harvested from the tibia or the iliac crest.
2.3 Biomaterials for Guided Bone Regeneration
2.3.1 Bone Graft Materials
Bone graft materials can be classified according to their source of origin. Each class possesses different capability for regeneration of bone. The most ideal graft material in terms of regeneration potency is the autogenous bone graft which has osteogenetic properties. However application of autogenous bone graft may be restricted. Furthermore, in particular instances of graft material under constant pressure, the autogenous bone graft may fail to secure the graft space. The rapid turnover rate may be problematic. In summary, non-autogenous bone grafts are not simply alternatives to autogenous but may be the best option we have for specific cases.
In Korea, various non-autogenous graft materials are commercially available for clinical use. These allogenic, xenogenic and alloplastic bone graft materials are recommended for small minor bone defects in combination with the guided bone regeneration technique.
184.108.40.206 Allogenic Bone Graft
Allogenic bone graft material originates from human individuals other than the recipient individual, genetically. Bone banks typically accumulate allogenic bone grafts from two donor sources, namely cadaveric and living donors who are undergoing bone removal procedures. Three forms of allogenic bone graft are available. Fresh or fresh-frozen allograft, freeze dried bone allograft and demineralized freeze dried bone allograft. When applying allografts for bone augmentation, the risk of disease transmission is of concern. Fortunately, according to the Centers for Disease Control and Prevention, there have been no reports of disease transmission when freeze-dried types of allograft are used for periodontal procedures.
Advantage of the allogenic grafts over the other bone graft materials is that these grafts can carry osteoinductive properties. Xenogenic and alloplastic bone graft materials are only osteoconductive at the best, unless they are enhanced by bioengineering techniques.
Allogenic bone graft materials available and currently in clinical use in Korea are as in the following. Demineralized freeze-dried form of allografts are Grafton®, Orthoblast II®, Tutoplast®, Regenafil®, and SureFuse®. Freeze-dried bones include Puros®, OraGraft® and ICB®.
220.127.116.11 Xenogenic Bone Graft
Xenogenic bone grafts are harvested and processed from other species than human. Bovine bone is the most representative. This class of bone graft materials is accepted to have only osteoconductive properties. Commercially available products include Bio-Oss®, BioCera®, Biogen®, Osteoplant ®, OSC-B®, and NuOss®.
Both allogenic and xenogenic bone graft materials can be applied for subantral augmentation. Regardless of the residual alveolar bone height, if it provides sufficient initial stability for the implant fixture, bone graft and implant installation can be performed simultaneously. If initial stability is not obtained, implant installation should be delayed for a recommended period of 9 to 12 months after subantral bone graft.
18.104.22.168 Alloplastic Bone Graft
Alloplastic bone graft materials are usually synthetic in its origin and are known to have only osteoconductive properties. Products consisting of sole or combinations of hydroxyapatite, calcium carbonate and beta tricalcium phosphate are available. Examples from Korean markets are Calcitite HA®, Osteon, Osteograft®, Frios®, Algipore®, OsteoGen®, HA Resorb® for sole hydroxyapatite, CeraSorb®, InduCera®, Biobase® for sole β-TCP, MBCP® for combination of hydroxyapatite and β-TCP, and Biocoral®, Interpore®, SIC nature bone® for sole calcium carbonate.
Alloplastic bone graft materials are often produced in combination with osteoinductive substances in Korea and sold in the market. Hydroxyapatite mixed with rhBMP-2 such as Novosis®, β-TCP mixed with rhBMP-2 such as Cowell BMP®, and products containing biphasic calcium phosphate lyophilized with rhBMP-2 materials are also available. β-TCP mixed with rhBMP-2 and bio-degradable Hydrogel is produced as an injectable putty with a trade name Exelos Inject®.
2.3.2 Bioengineering Techniques
Ideal bone graft materials should exhibit not only osteoconductive properties but as well osteoinductive. They should also provide a favorable environment for the invading blood vessels and bone forming cells. Recently various basic and clinical researches on the effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) and potential use of human multipotent mesenchymal stromal/stem cells (MSC) are being reported and investigated.
Bone morphogenetic protein was first introduced by Urist in 1965 as a consisting substance of a decalcified bone . Several different types of the protein are classified now with approval of products containing bone morphogenetic protein 2 and 7 for orthopedic application by the FDA.
Current focus of investigation concerning rhBMP-2 is concentrated on the carrier of the growth factor. Carriers of rhBMP-2 are required to have properties that will make possible to control the release of rhBMP-2 to the bone defect. Uncontrolled release of rhBMP-2 not only diminishes its effectiveness but also may induce concentration related side effects. Currently in our institute, both combination of collagen hydrogel, nano-hydroxyapatite and rhBMP-2 coated on dental implant surface and poloxamer based hydrogel with rhBMP-2 are under investigation.
22.214.171.124 Autologous Bone Marrow Mesenchymal Stem Cells
2.4 Alveolar Ridge Augmentation by Distraction Osteogenesis
In general, the available amount of soft tissue for wound closure restricts the capacity of bone grafting. Soft tissue coverage is crucial. Otherwise infection over the graft material may occur. Graft materials could be lost. At the best, the attained bone augmentation will be far behind than required.
Alveolar distraction osteogenesis (DO) is the most recent approach for alveolar ridge augmentation with promising results. Unlike any other approaches for alveolar ridge augmentation, DO is capable of lengthening both the hard and soft tissue. This method has the advantage of preserving the transport part of alveolar crest with intact vascularized nourished bone. This property permits the amount of alveolar augmentation attained by DO to surpass what the conventional methods of bone grafting would possibly do.
2.4.1 Distraction Techniques
The span of the edentulous alveolar ridge should be at least two teeth wide in purpose to apply this technique. Otherwise the transport segment is under a risk of resorption during distraction. When the span of the alveolar ridge that requires distraction becomes larger, it can be segmented according to the vector of distraction required.
2.4.2 Possible Amount of Bone Gain: Clinical Outcome
In a clinical study reported by Paeng et al. in 2006, 25 patients who have undergone alveolar ridge augmentation by DO and subsequent installation of total 84 dental implants were investigated. Average amount of augmentation was 9.8 ± 3.4 mm. All of the implants installed survived for an average follow up period of 13.5 months. They suggested that DO may be acknowledged as a viable treatment option for alveolar augmentation so far . In another case series of four patients who underwent alveolar distraction of the anterior atrophic mandible for dental implants, Yeom et al. reported that an average of 11.38 ± 1.38 mm vertical gain was obtained by distraction . DO can also be applied for augmentation of a reconstructed mandible with vascularized fibular free flap. Paeng et al. stressed that despite a tendency of surgical site infection during distraction of the fibular bone, undisturbed bone regeneration occurs for successful dental implant installation .
2.4.3 Consolidation Enhancement Factors
Current studies on DO of the alveolar bone are focused on the consolidation enhancement factors. The purpose of these studies is to develop a novel method to shorten the consolidation time and at the same time to enhance the mechanical property of the newly distracted bone. Both biological and mechanical stimulations are under research.
Kim et al. reported that significant amount of new bone volume was observed when human mesenchymal stromal cells were injected to the distraction site one day before distraction initiation in a rabbit mandibular distraction model. Human mesenchymal stromal cells also increased bone mineral density .
Growth factors are also candidates. Floerkemeier et al. demonstrated that percutaneous triple injection of rhBMP-2 improves trabecular microarchitecture of the regenerated bone and in turn contributes to advanced mechanical integrity . Fugio et al. suggested that failure of high speed DO attributes to lack of bone marrow endothelial cells and endothelial progenitor cells into the gap formed by distraction. In their study, stromal cell derived factor 1 showed possibility to overcome the resulting ischemic condition and facilitate acceleration of distraction speed .
Mechanical means of consolidation enhancement include electric, laser, and ultrasonic stimulations. Hwang et al. investigated the effect of pulsed electromagnetic field stimulation on consolidation of the distracted callus with results of enhanced bone formation. In their study, they applied the pulsed electromagnetic field stimulation for 5 days at the beginning of the consolidation period . Miloro et al. studied the effect of low-level laser on DO. They found that lower-level laser when applied after each activations of distraction device accelerates bone regeneration . The effect of low-intensity pulsed ultrasound when applied during the consolidation period had been reported by Shimazaki et al. They reported that not only normal distraction protocol but also a rapid distraction protocol may benefit from the application of low-intensity pulse ultrasound .
The author would like to thank professor Jong-Ho Lee, Soon-Jung Hwang, Soung-Min Kim and doctor Kang-Mi Pang, Ju-Hyun Kim and Seung-Ki Min of the School of Dentistry, Seoul National University for their help provided in preparing this manuscript.
- 7.Paeng JY, Myoung H, Hwang SJ, Seo BM, Choi JY, Lee JH, et al. Clinical evaluation of alveolar distraction osteogenesis for implant installation. J Korean Assoc Maxillofac Plast Reconstr Surg. 2006;28(4):329–38.Google Scholar
- 8.Yeom HR, Jeon SH, Kim YT, Paeng JY, Ahn KM, Myung H, et al. Implant installation using vertical distraction osteogenesis at a severely atrophied edentulous mandible. J Korean Assoc Maxillofac Plast Reconstr Surg. 2006;28(2):154–65.Google Scholar
- 9.Paeng JY, Lee JY, Myoung H, Hwang SJ, Seo BM, Choi JY, et al. Vertical distraction osteogenesis for implant installation on the reconstructed mandible with free fibular flap. J Korean Assoc Maxillofac Plast Reconstr Surg. 2006;28(6):579–85.Google Scholar
- 11.Pastor MF, Floerkemeier T, Witte F, Nellesen J, Thorey F, Windhagen H, et al. Repetitive recombinant human bone morphogenetic protein 2 injections improve the callus microarchitecture and mechanical stiffness in a sheep model of distraction osteogenesis. Orthop Rev. 2012;4(1):e13. doi: 10.4081/or.2012.e13.CrossRefGoogle Scholar
- 12.Fujio M, Yamamoto A, Ando Y, Shohara R, Kinoshita K, Kaneko T, et al. Stromal cell-derived factor-1 enhances distraction osteogenesis-mediated skeletal tissue regeneration through the recruitment of endothelial precursors. Bone. 2011;49(4):693–700. doi: 10.1016/j.bone.2011.06.024.PubMedCrossRefGoogle Scholar
- 13.Hwang KK, Cho TH, Song YM, Kim DK, Han SH, Kim IS, et al. Effect of pulsed electromagnetic field stimulation on the early bone consolidation after distraction osteogenesis in rabbit mandible model. J Korean Assoc Maxillofac Plast Reconstr Surg. 2007;29(2):123–31.Google Scholar
Open Access This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.