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Neuroimaging of Dementia with Lewy Bodies

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Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias

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Abstract

Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia following Alzheimer’s disease (AD). Despite the development of consensus diagnostic criteria, differentiating DLB from other types of dementia, such as AD, can be difficult. Several imaging studies are currently underway to differentiate DLB from other types of dementia. Magnetic resonance imaging of DLB shows preservation of the medial temporal lobe structure and predominant atrophy of subcortical structures, including the substantia innominata and dorsal midbrain, compared with AD. Decreased perfusion in the occipital lobe and relatively increased perfusion in the deep gray matter (striatum and thalamus) on single photon emission CT (SPECT) are shown to be characteristic features of DLB. MIBG myocardial scintigraphy provides a higher sensitivity and higher specificity for diagnosing probable DLB from AD than perfusion SPECT. Dopamine transporter imaging, an available technique in Japan since 2014, shows good diagnostic accuracy for DLB. The international consensus criteria for DLB (2005) incorporate abnormal imaging on dopamine transporter as a supportive feature. As idiopathic REM sleep behavior disorder (iRBD) is considered to be a prodromal stage of alpha-synucleinopathies, the above findings are observed in some patients with iRBD. This review summarizes the applications and findings from neuroimaging studies of DLB and iRBD.

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References

  1. McKeith IG, Dickson DW, Lowe J, et al. Consortium on DLB. Diagnosis and management of dementia with Lewy bodies; third report of the DLB consortium. Neurology. 2005;65:1863–72.

    Google Scholar 

  2. Namioka N, Hanyu H, Hatanaka H, et al. Comprehensive geriatric assessment in elderly patients with dementia. Geriatr Gerontl Int Aug. 2014;15(1):27–33.

    Article  Google Scholar 

  3. Hanyu H, Sato T, Hirao K, et al. Differences in clinical course between dementia with Lewy bodies and Alzheimer’s disease. Eur J Neurol. 2009;16:212–7.

    Article  CAS  PubMed  Google Scholar 

  4. Taylor J-P, O’Brien J. Neuroimaging of dementia with Lewy bodies. Neuroimaging Clin N Am. 2012;22:67–81.

    Article  PubMed  Google Scholar 

  5. Sinha N, Firebank M, O’Brien JT. Biomarkers in dementia with Lewy bodies: a review. Int J Geraitr Psychiatry. 2012;27:443–53.

    Article  Google Scholar 

  6. Watson R, Blamire AM, O’Brien JT. Magnetic resonance imaging in Lewy body dementias. Dement Geriatr Cogn Disord. 2009;28:493–506.

    Article  PubMed  Google Scholar 

  7. Burton EJ, Barber R, Mukaetova-Ladinska EB, et al. Medial temporal lobe atrophy on MRI differentiate Alzheimer’s disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis. Brain. 2009;132:195–203.

    Article  CAS  PubMed  Google Scholar 

  8. Hirata Y, Matsuda H, Nemoto K, et al. Voxel-based morphometry to discriminate early Alzheimer’s disease from controls. Neurosci Lett. 2005;382:269–74.

    Article  CAS  PubMed  Google Scholar 

  9. Sabattoli F, Boccardi M, Galluzzi S, et al. Hippocampal shape differences in dementia with Lewy bodies. NeuroImage. 2008;41:699–705.

    Article  CAS  PubMed  Google Scholar 

  10. Hanyu H, Shimizu S, Tanaka Y, et al. Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer’s disease. Neurosci Lett. 2005;380:166–9.

    Article  CAS  PubMed  Google Scholar 

  11. Hanyu H, Shimizu S, Tanaka Y, et al. MR features of the substantia innominata and therapeutic implications in dementias. Neurobiol Aging. 2007;28:548–54.

    Article  PubMed  Google Scholar 

  12. Whitwell JL, Weigand SD, Shiung MM, et al. Focal atrophy in dementia with Lewy bodies on MRI: a distinct pattern from Alzheimer’s disease. Brain. 2007;130:708–19.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Shimizu S, Hanyu H, Kanetaka H, et al. Differentiation of dementia with Lewy bodies from Alzheimer’s disease using brain SPECT. Dement Geriatr Cogn Disord. 2005;20:25–30.

    Article  PubMed  Google Scholar 

  14. Mosconi L, Tsui WH, Herholz K, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. J Nucl Med. 2008;49:390–8.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Hanyu H, Shimizu S, Hirao K, et al. Differentiation of dementia with Lewy bodies from Alzheimer’s disease using mini-mental state examination and brain perfusion SPECT. J Neurol Sci. 2006;250:97–102.

    Article  PubMed  Google Scholar 

  16. Lim SM, Katsifits A, Villemagne VL, et al. The 18F-FDG PET cingulate island sign and comparison to 123I-β-CIT SPECT for diagnosis of dementia with Lewy bodies. J Nucl Med. 2009;50:1638–45.

    Article  CAS  PubMed  Google Scholar 

  17. Sato T, Hanyu H, Hirao K, et al. Deep gray matter hyperperfusion with occipital hypoperfusion in dementia with Lewy bodies. Eur J Neurol. 2007;14:1299–301.

    Article  CAS  PubMed  Google Scholar 

  18. Nagahama Y, Okina T, Suzuki N, et al. Neural correlates of psychotic symptoms in dementia wit Lewy bodies. Brain. 2010;133:557–67.

    Article  PubMed  Google Scholar 

  19. O’Brien JT, Firbank MJ, Mosimann UP, et al. Changes in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies. Psychiatry Res. 2005;139:79–88.

    Article  PubMed  Google Scholar 

  20. Hanyu H, Shimizu S, Hirao K, et al. Comparative value of brain perfusion SPECT and [123I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2006;33:248–53.

    Article  PubMed  Google Scholar 

  21. Hanyu H, Shimizu S, Hirao K, et al. The role of [123I] MIBG myocardial scintigraphy for the diagnosis of Lewy body disease in patients with dementia in a memory clinic. Dement Geriatr Cogn Disord. 2006;22:379–84.

    Article  PubMed  Google Scholar 

  22. McKeith I, O’Brien J, Walker Z, et al. Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007;6:305–13.

    Article  PubMed  Google Scholar 

  23. Walker Z, Jaros E, Walker RWH, et al. Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry. 2007;78:1176–81.

    Article  PubMed  PubMed Central  Google Scholar 

  24. O’Brien JT, McKeith IG, Walker Z, et al. Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies. Br J Psychiatry. 2009;1194:34–9.

    Article  Google Scholar 

  25. Treglia G, Cason E, Cortelli P, et al. Iodine-123 metaiodobenzylguanidine scintigraphy and iodine-123 ioflupane single photon emission computed tomography in Lewy body diseases: complementary or alternative techniques? J Neuroimaging. 2014;24:149–54.

    Article  PubMed  Google Scholar 

  26. Hort J, O’Brien JT, Gainotti G, et al. EFNS guidelines for the diagnosis and management of Alzheimer’s disease. Eur J Neurol. 2010;17:1236–48.

    Article  CAS  PubMed  Google Scholar 

  27. Hanyu H, Inoue Y, Sakurai H, et al. Voxel-based magnetic resonance imaging study of structural brain changes in patients with idiopathic REM sleep behavior disorder. Parkinsonism Relat Disord. 2012;18:136–9.

    Article  PubMed  Google Scholar 

  28. Scherfler C, Frauscher B, Schocke M, et al. White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometric study. Ann Neurol. 2011;69:400–4007.

    Article  PubMed  Google Scholar 

  29. Hanyu H, Inoue Y, Sakurai H, et al. Regional cerebral blood flow changes in patients with idiopathic REM sleep behavior disorder. Eur J Neurol. 2011;18:784–8.

    Article  CAS  PubMed  Google Scholar 

  30. Sakurai H, Hanyu H, Inoue Y, et al. Longitudinal study of regional cerebral blood flow in elderly patients with idiopathic rapid eye movement sleep behavior disorder. Geriatr Gerontol Int. 2014;14:115–20.

    Article  PubMed  Google Scholar 

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Acknowledgments

We are grateful to Maya Vardaman and Associate Professor Edward F. Barroga of the Department of International Medical Communications of Tokyo Medical University for reviewing and editing the manuscript.

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Authors and Affiliations

  1. Department of Geriatric Medicine, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Haruo Hanyu MD, PhD

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  1. Haruo Hanyu MD, PhD
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Correspondence to Haruo Hanyu MD, PhD .

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Editors and Affiliations

  1. Integrative Brain Imaging Center, National Center of Neurology & Psychiatry, Kodaira, Tokyo, Japan

    Hiroshi Matsuda

  2. Department of Psychiatry, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Takashi Asada

  3. Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan

    Aya Midori Tokumaru

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Hanyu, H. (2017). Neuroimaging of Dementia with Lewy Bodies. In: Matsuda, H., Asada, T., Tokumaru, A. (eds) Neuroimaging Diagnosis for Alzheimer's Disease and Other Dementias. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55133-1_12

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  • DOI: https://doi.org/10.1007/978-4-431-55133-1_12

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-55132-4

  • Online ISBN: 978-4-431-55133-1

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