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Zinc Signaling by “Zinc Wave”

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Zinc Signals in Cellular Functions and Disorders

Abstract

Zinc (Zn) is an essential heavy metal for all organisms. Zn homeostasis is maintained in mammalian cells through the activity of Zn transporters and Zn-permeable channels and through metallothionein expression levels. Zn is important in nucleic acid metabolism, cell replication, and tissue growth and repair. Zn deficiency is associated with a wide range of pathological conditions, such as impaired immunity, growth retardation, disorders in brain development, and delayed wound healing. Zn binds and affects the activity of several signaling molecules and of transcription factors that have a Zn-binding motif. However, whether Zn itself, as does calcium, acts as an intracellular signaling molecule has been a point of speculation. Recently, we and other groups have demonstrated that Zn does indeed act as an intracellular signaling molecule, converting extracellular stimuli to intracellular signals and controlling various cell functions. This chapter summarizes our current understanding of Zn signaling, especially with regard to the Zn wave and the role of Zn signaling in immune cells, and discusses how these processes contribute to allergic responses.

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Authors and Affiliations

  1. Laboratory of Immune Regulation, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, 513-8670, Japan

    Keigo Nishida Ph.D.

  2. Laboratory for Homeostatic Network, RCAI, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa, 230-0045, Japan

    Keigo Nishida Ph.D. & Satoru Yamasaki Ph.D.

Authors
  1. Keigo Nishida Ph.D.
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  2. Satoru Yamasaki Ph.D.
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Correspondence to Keigo Nishida Ph.D. .

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Editors and Affiliations

  1. Laboratory for Homeostatic Network, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan

    Toshiyuki Fukada

  2. Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

    Taiho Kambe

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Nishida, K., Yamasaki, S. (2014). Zinc Signaling by “Zinc Wave”. In: Fukada, T., Kambe, T. (eds) Zinc Signals in Cellular Functions and Disorders. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55114-0_5

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