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Zinc Signaling and Cancer

  • Thirayost Nimmanon
  • Kathryn M. TaylorEmail author
Chapter

Abstract

The intracellular level of zinc is tightly controlled by ZnT (SLC30A) and ZIP (SLC39A) zinc transport proteins, as well as zinc-binding proteins such as metallothioneins. The ZIP channels are responsible for zinc influx into the cytoplasm, either from the extracellular space or intracellular storage compartments, such as the endoplasmic reticulum and the Golgi, whereas the ZnT transporters transport zinc in the opposite direction. Malfunctions of some zinc transport proteins, resulting in cellular zinc dyshomeostasis and subsequent effects on zinc signaling pathways, have been associated with cancer in a tissue-specific manner. In this chapter we detail what is known about the association between zinc channel and transporter dysregulations and the impact that this has on zinc signaling in different cancers. A particular emphasis is placed on the types of cancer in which the role of zinc dyshomeostasis on carcinogenesis or cancer progression has been most thoroughly investigated, including cancers of the breast, prostate, liver, pancreas, and colorectum. Posttranslational modification by phosphorylation as a novel regulatory mechanism of ZIP channels is also discussed as an important mechanism that may provide a clinical biomarker or target mechanism.

Keywords

Cancer SLC30A SLC39A Zinc channel Zinc transport ZIP6 ZIP7 

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© Springer Japan 2014

Authors and Affiliations

  1. 1.Cardiff School of Pharmacy and Pharmaceutical Sciences, Redwood BuildingCardiff UniversityCardiffUK

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