Abstract
In recent years, roles of the immune system in immune surveillance of cancer have been explored. And natural killer (NK) cells are considered to be critical players in anticancer immunity. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells.
In this review, I mentioned the role of NK cell receptors, therapeutic NK cells, and NK cell modulation in order to enhance anticancer immunity. Namely, I discuss on some of the implications of the various findings with respect to possible therapeutic approaches.
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References
Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song YJ, Yang L et al (2005) Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436(7051):709–713
Sun K, Alvarez M, Ames E, Barao I, Chen M, Longo DL et al (2012) Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood. doi:10.1182/blood-2011-08-374314
Tarek N, Le Luduec JB, Gallagher MM, Zheng J, Venstrom JM, Chamberlain E et al (2012) Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J Clin Invest. doi:10.1172/JCI62749
Raulet DH, Vance RE (2006) Self-tolerance of natural killer cells. Nat Rev Immunol 6(7):520–531
Orr MT, Lanier LL (2010) Natural killer cell education and tolerance. Cell 142(6):847–856. doi:10.1016/j.cell.2010.08.031
Jung H, Hsiung B, Pestal K, Procyk E, Raulet DH (2012) RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. J Exp Med 209(13):2409–2422. doi:10.1084/jem.20120565
Hershkovitz O, Rosental B, Rosenberg LA, Navarro-Sanchez ME, Jivov S, Zilka A et al (2009) NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells. J Immunol 183(4):2610–2621. doi:10.4049/jimmunol.0802806
Garg A, Barnes PF, Porgador A, Roy S, Wu S, Nanda JS et al (2006) Vimentin expressed on mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor. J Immunol 177(9):6192–6198
Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L et al (2009) NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest 119(5):1251–1263. doi:10.1172/JCI36022
Hallett WH, Murphy WJ (2006) Positive and negative regulation of natural killer cells: therapeutic implications. Semin Cancer Biol 16(5):367–382
Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE et al (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. N Engl J Med 313(23):1485–1492
Krause SW, Gastpar R, Andreesen R, Gross C, Ullrich H, Thonigs G et al (2004) Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial. Clin Cancer Res 10(11):3699–3707
Parkhurst MR, Riley JP, Dudley ME, Rosenberg SA (2011) Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression. Clin Cancer Res 17(19):6287–6297. doi:10.1158/1078-0432.CCR-11-134
Stern M, Passweg JR, Meyer-Monard S, Esser R, Tonn T, Soerensen J et al (2013) Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers. Bone Marrow Transplant 48(3):433–438. doi:10.1038/bmt.2012.162
Rizzieri DA, Storms R, Chen DF, Long G, Yang Y, Nikcevich DA et al (2010) Natural killer cell-enriched donor lymphocyte infusions from A 3–6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation. Biol Blood Marrow Transplant 16(8):1107–1114. doi:10.1016/j.bbmt.2010.02.018
Tam YK, Maki G, Miyagawa B, Hennemann B, Tonn T, Klingemann HG et al (1999) Characterization of genetically altered, interleukin 2-independent natural killer cell lines suitable for adoptive cellular immunotherapy. Hum Gene Ther 10(8):1359–1373
Iliopoulou EG, Kountourakis P, Karamouzis MV, Doufexis D, Ardavanis A, Baxevanis CN et al (2010) A phase I trial of adoptive transfer of allogeneic natural killer cells in patients with advanced non-small cell lung cancer. Cancer Immunol Immunother 59(12):1781–1789. doi:10.1007/s00262-010-0904-3
Gong JH, Maki G, Klingemann HG et al (1994) Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells. Leukemia 8(4):652–658
Yan Y, Steinherz P, Klingemann HG, Dennig D, Childs BH, McGuirk J et al (1998) Antileukemia activity of a natural killer cell line against human leukemias. Clin Cancer Res 4(11):2859–2868
Tam YK, Miyagawa B, Ho VC, Klingemann HG (1999) Immunotherapy of malignant melanoma in a SCID mouse model using the highly cytotoxic natural killer cell line NK-92. J Hematother 8(3):281–290
Maki G, Klingemann HG, Martinson JA, Tam YK et al (2001) Factors regulating the cytotoxic activity of the human natural killer cell line, NK-92. J Hematother Stem Cell Res 10(3):369–383
Klingemann HG, Wong E, Maki GA (1996) A cytotoxic NK-cell line (NK-92) for ex vivo purging of leukemia from blood. Biol Blood Marrow Transplant 2(2):68–75
Semino C, Martini L, Queirolo P, Cangemi G, Costa R, Alloisio A et al (1999) Adoptive immunotherapy of advanced solid tumors: an eight year clinical experience. Anticancer Res 19(6C):5645–5649
Arai S, Meagher R, Swearingen M, Myint H, Rich E, Martinson J et al (2008) Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial. Cytotherapy 10(6):625–632. doi:10.1080/14653240802301872
Klingemann HG (2005) Natural killer cell-based immunotherapeutic strategies. Cytotherapy 7(1):16–22
Sutlu T, Alici E (2009) Natural killer cell-based immunotherapy in cancer: current insights and future prospects. J Intern Med 266(2):154–181. doi:10.1111/j.1365-2796.2009.02121.x
Rosenstein M, Ettinghausen SE, Rosenberg SA et al (1986) Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2. J Immunol 137(5):1735–1742
Meropol NJ, Porter M, Blumenson LE, Lindemann MJ, Perez RP, Vaickus L et al (1996) Daily subcutaneous injection of low-dose interleukin 2 expands natural killer cells in vivo without significant toxicity. Clin Cancer Res 2(4):669–677
Hallett WH, Ames E, Alvarez M, Barao I, Taylor PA, Blazar BR et al (2008) Combination therapy using IL-2 and anti-CD25 results in augmented natural killer cell-mediated antitumor responses. Biol Blood Marrow Transplant 14(10):1088–1099. doi:10.1016/j.bbmt.2008.08.001
Ames E, Hallett WH, Murphy WJ (2009) Sensitization of human breast cancer cells to natural killer cell-mediated cytotoxicity by proteasome inhibition. Clin Exp Immunol 155(3):504–513. doi:10.1111/j.1365-2249.2008.03818.x
Tanaka J, Sugita J, Shiratori S, Shigematsu A, Imamura M (2012) Dasatinib enhances the expansion of CD56+CD3- NK cells from cord blood. Blood 119(25):6175–6176. doi:10.1182/blood-2012-03-416800
Borg C, Terme M, Taïeb J, Ménard C, Flament C, Robert C (2004) Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J Clin Invest 114(3):379–388
Skov S, Pedersen MT, Andresen L, Straten PT, Woetmann A, Odum N (2005) Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3-dependent expression of MHC class I-related chain A and B. Cancer Res 65(23):11136–11145
Khuu H, Bettera DM, Cook L (2010) Adoptive transfer of escalating doses of ex vivo expanded autologous natural killer (NK) dells in patients with advanced malignancies following bortezomib treatment to sensitize to NK-TRAIL cytotoxicity. Blood 116:4296
Bellucci R, Nguyen HN, Martin A, Heinrichs S, Schinzel AC, Hahn WC et al (2012) Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells. J Clin Invest 122(7):2369–2383. doi:10.1172/JCI58457. Epub 2012 Jun 11
Hsu AK, Quach H, Tai T, Prince HM, Harrison SJ, Trapani JA et al (2011) The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy. Blood 117(5):1605–1613. doi:10.1182/blood-2010-04-278432. Epub 2010 Oct 26
Krusch M, Salih J, Schlicke M, Baessler T, Kampa KM, Mayer F et al (2009) The kinase inhibitors sunitinib and sorafenib differentially affect NK cell antitumor reactivity in vitro. J Immunol 183(12):8286–8294. doi:10.4049/jimmunol.0902404
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Kokura, S. (2016). Natural Killer Cells. In: Yamaguchi, Y. (eds) Immunotherapy of Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55031-0_7
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DOI: https://doi.org/10.1007/978-4-431-55031-0_7
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