Abstract
Patients with chorionic ischemic heart disease including irreversible myocardial damage cannot be completely restored by conventional coronary artery revascularization including coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI).
Cell transplantation therapy for these patients has advantageous potential to improve left ventricle function with preventing ventricular remodeling and contractility of ventricle reduction. A number of animal studies have shown that intramyocardial cell transplantation in ischemic cardiomyopathy is associated with an improvement in ventricle function and consequently several clinical trials have evaluated clinical effectiveness of these therapies.
Various type of cell and methods have been used for intramyocardial cell transplantation; however, cell types with clinical utilization are bone marrow stem cell and skeletal myoblast.
Especially, intramyocardial bone marrow stem cell transplantation combined with CABG is a safe and available procedure with evidence of improving the left ventricle function in patients with chorionic ischemic heart disease. Furthermore, using off-pump CABG (OPCAB) technique may reduce intra- and postoperative complications in patients who have low cardiac function caused by prior myocardial infarction. Although the selection of patients is carefully treated, this combination therapy of cell transplantation and OPCAB can be advantageous option for ischemic heart disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schümichen C, Nienaber CA, Freund M, Steinhoff G (2003) Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361(9351):45–46
Menasché P, Hagège AA, Scorsin M, Pouzet B, Desnos M, Duboc D, Schwartz K, Vilquin JT, Marolleau JP (2001) Myoblast transplantation for heart failure. Lancet 357(9252):279–280
Patel AN, Geffner L, Vina RF, Saslavsky J, Urschel HC Jr, Kormos R, Benetti F (2005) Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study. J Thorac Cardiovasc Surg 130(6):1631–1638. Epub 2005 Oct 26
Hendrikx M, Hensen K, Clijsters C, Jongen H, Koninckx R, Bijnens E, Ingels M, Jacobs A, Geukens R, Dendale P, Vijgen J, Dilling D, Steels P, Mees U, Rummens JL (2006) Recovery of regional but not global contractile function by the direct intramyocardial autologousbone marrow transplantation: results from a randomized controlled clinical trial. Circulation 114(1 Suppl):I101–I107
Stamm C, Kleine HD, Choi YH, Dunkelmann S, Lauffs JA, Lorenzen B, David A, Liebold A, Nienaber C, Zurakowski D, Freund M, Steinhoff G (2007) Intramyocardial delivery of CD133 + bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J Thorac Cardiovasc Surg 133(3):717–725. Epub 2007 Feb 1
Ang KL, Chin D, Leyva F, Foley P, Kubal C, Chalil S, Srinivasan L, Bernhardt L, Stevens S, Shenje LT, Galiñanes M (2008) Randomized, controlled trial of intramuscular or intracoronary injection of autologous bone marrow cells into scarred myocardium during CABG versus CABG alone. Nat Clin Pract Cardiovasc Med 5(10):663–670. doi:10.1038/ncpcardio1321. Epub 2008 Aug 19
Zhao Q, Sun Y, Xia L, Chen A, Wang Z (2008) Randomized study of mononuclear bone marrow cell transplantation in patients with coronary surgery. Ann Thorac Surg 86(6):1833–1840. doi:10.1016/j.athoracsur.2008.08.068
Hu S, Liu S, Zheng Z, Yuan X, Li L, Lu M, Shen R, Duan F, Zhang X, Li J, Liu X, Song Y, Wang W, Zhao S, He Z, Zhang H, Yang K, Feng W, Wang X (2011) Isolated coronary artery bypass graft combined with bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: a single-center, randomized, double-blind, placebo-controlled clinical trial. J Am Coll Cardiol 57(24):2409–2415. doi:10.1016/j.jacc.2011.01.037
Yerebakan C, Kaminski A, Westphal B, Donndorf P, Glass A, Liebold A, Stamm C, Steinhoff G (2011) Impact of preoperative left ventricular function and time from infarction on the long-term benefits after intramyocardial CD133(+) bone marrow stem cell transplant. J Thorac Cardiovasc Surg 142(6):1530–1539.e3. doi: 10.1016/j.jtcvs.2011.05.002. Epub 2011 Jun 12
Strauer BE, Steinhoff G (2011) 10 years of intracoronary and intramyocardial bone marrow stem cell therapy of the heart: from the methodological origin to clinical practice. J Am Coll Cardiol 58(11):1095–1104. doi:10.1016/j.jacc.2011.06.016. Review
Dib N, Michler RE, Pagani FD, Wright S, Kereiakes DJ, Lengerich R, Binkley P, Buchele D, Anand I, Swingen C, Di Carli MF, Thomas JD, Jaber WA, Opie SR, Campbell A, McCarthy P, Yeager M, Dilsizian V, Griffith BP, Korn R, Kreuger SK, Ghazoul M, MacLellan WR, Fonarow G, Eisen HJ, Dinsmore J, Diethrich E (2005) Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year follow-up. Circulation 112(12):1748–1755
Gavira JJ, Herreros J, Perez A, Garcia-Velloso MJ, Barba J, Martin-Herrero F, Cañizo C, Martin-Arnau A, MartÃ-Climent JM, Hernández M, López-Holgado N, González-Santos JM, MartÃn-Luengo C, Alegria E, Prósper F (2006) Autologous skeletal myoblast transplantation in patients with nonacute myocardial infarction: 1-year follow-up. J Thorac Cardiovasc Surg 131(4):799–804
Zhang D, Wang L, Zhang F, Li C, Zhu T, Cao K, Ma W, Yang Z (2013) Nine-year follow-up of local implantation of autologous skeletal myoblasts in a patient with coronary heart disease. Am J Case Rep 14:139–142. doi:10.12659/AJCR.883903. Print 2013
Menasché P, Alfieri O, Janssens S, McKenna W, Reichenspurner H, Trinquart L, Vilquin JT, Marolleau JP, Seymour B, Larghero J, Lake S, Chatellier G, Solomon S, Desnos M, Hagège AA (2008) The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 117(9):1189–1200. doi:10.1161/CIRCULATIONAHA.107.734103. Epub 2008 Feb 19
Nagamine H, Watanabe G, Shiobara S, Takemura H, Arai S, Tomita S (2004) Intramyocardial CD34 + cell transplantation combined with off-pump coronary artery bypass grafting. Heart Surg Forum 7(4):E285–E287
Donndorf P, Kundt G, Kaminski A, Yerebakan C, Liebold A, Steinhoff G, Glass A (2011) Intramyocardial bone marrow stem cell transplantation during coronary artery bypass surgery: ameta-analysis. J Thorac Cardiovasc Surg 142(4):911–920. doi:10.1016/j.jtcvs.2010.12.013. Epub 2011 Mar 3. Review
Shudo Y, Miyagawa S, Fukushima S, Saito A, Shimizu T, Okano T, Sawa Y (2011) Novel regenerative therapy using cell-sheet covered with omentum flap delivers a huge number of cells in a porcine myocardial infarction model. J Thorac Cardiovasc Surg 142(5):1188–1196. doi:10.1016/j.jtcvs.2011.07.002. Epub 2011 Sep 14
Kanamori T, Watanabe G, Yasuda T, Nagamine H, Kamiya H, Koshida Y (2006) Hybrid surgical angiogenesis: omentopexy can enhance myocardial angiogenesis induced by cell therapy. Ann Thorac Surg 81(1):160–167
Kawamura M, Miyagawa S, Fukushima S, Saito A, Miki K, Ito E, Sougawa N, Kawamura T, Daimon T, Shimizu T, Okano T, Toda K, Sawa Y (2013) Enhanced survival of transplanted human induced pluripotent stem cell-derived cardiomyocytes by the combination of cell sheets with the pedicled omental flap technique in a porcine heart. Circulation 128(11 Suppl 1):S87–S94. doi: 10.1161/CIRCULATIONAHA.112.000366
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Japan
About this chapter
Cite this chapter
Tomita, S., Watanabe, G. (2016). OPCAB Combined Regenerative Surgery. In: Asai, T., Ochi, M., Yokoyama, H. (eds) Off-Pump Coronary Artery Bypass. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54986-4_29
Download citation
DOI: https://doi.org/10.1007/978-4-431-54986-4_29
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54985-7
Online ISBN: 978-4-431-54986-4
eBook Packages: MedicineMedicine (R0)