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Patient Management OPCAB

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Off-Pump Coronary Artery Bypass
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Abstract

Patient management is important particularly in OPCAB from the standpoint of a hypercoagulability state and an occasional complication of AF after surgery.

Hypercoagulability state after OPCAB could potentially jeopardize early graft patency, as well as induce pulmonary infarction associated with deep vein thrombosis, and stroke, especially in atrial fibrillation. Accordingly, several institutions have tried an aggressive anticoagulation strategy with a continuous postoperative heparin administration for 2–5 days after surgery and early use of aspirin or clopidogrel in addition to aspirin. Furthermore, warfarin is administered by the majority of surgeons controlling INR at around 2.0, when vein grafts are selected for coronary revascularization.

In order to prevent AF after OPCAB, several trials and studies were performed in Japan focusing on the efficacy of perioperative beta-blocker administration, including intravenous landiolol hydrochloride treatment.

Annual alternation of CABG patients demonstrated that the percentage of the elderly aged over 80 years gradually increased from 5 % in 2000 to 11 % in 2012, in Japan. Postoperative care for elderly patients, prevention of respiratory complications, wound healing and infection, and mental confusion and delirium have come to be important.

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References

  1. Muriithi EW, Becker PR, Day SPA, Menus VC, Wheatley DJ (2000) Heparin-induced platelet dysfunction and cardiopulmonary bypass. Ann Thorac Surg 69:1827–1832

    Article  CAS  PubMed  Google Scholar 

  2. Paparella D, Galeone A, Venneri MT, Coviello M, Scrascia G, Marraudino N, Quaranta M, Luca Tupputi Schinosa L, Brister SJ (2006) Activation of the coagulation system during coronary artery bypass grafting: comparison between on-pump and off-pump techniques. J Thorac Cardiovasc Surg 131:290–297

    Article  PubMed  Google Scholar 

  3. Englberger L, Immer FF, Eckstein FS, Berdat PA, Haeberli A, Carrel TP (2004) Off-pump coronary artery bypass operation does not increase procoagulant and fibrinolytic activity: preliminary results. Ann Thorac Surg 77:1560–1566

    Article  PubMed  Google Scholar 

  4. Raja SG, Dreyfus GD (2006) Impact of off-pump coronary artery bypass surgery on postoperative bleeding: current best available evidence. J Card Surg 21:35–41

    Article  PubMed  Google Scholar 

  5. Diegeler A, Doll N, Rauch T, Haberer D, Walther T, Falk V et al (2000) Humoral immune response during coronary artery bypass grafting: a comparison of limited approach, “off-pump” technique, and conventional cardiopulmonary bypass. Circulation 102(19 Suppl 3):III95–III100

    CAS  PubMed  Google Scholar 

  6. MacGillivray TE, Vlahakes GJ (2004) Patency and the pump–the risks and benefits of off-pump CABG. N Engl J Med 350:3–4

    Article  CAS  PubMed  Google Scholar 

  7. Czerny M, Baumer H, Kilo J, Lassnigg A, Hamwi A, Vukovich T et al (2000) Inflammatory response and myocardial injury following coronary artery bypass grafting with or without cardiopulmonary bypass. Eur J Cardiothorac Surg 17:737–742

    Article  CAS  PubMed  Google Scholar 

  8. Chong AJ, Pohlman TH, Hampton CR et al (2003) Tissue factor and thrombin mediate myocardial ischemia-reperfusion injury. Ann Thorac Surg 75:S649–S655

    Article  PubMed  Google Scholar 

  9. Kloner RA, Jennings RB (2006) Consequences of brief ischemia: stunning, preconditioning, and their clinical implications: Part 2. Circulaton 104:3158–3167

    Article  Google Scholar 

  10. Kon ZN, Kwon MH, Collins MJ et al (2006) Off-pump coronary artery bypass leads to a regional hypercoagulable state not detectable using systemic markers. Innov (Phila) 1:232–238

    Article  Google Scholar 

  11. Okabayashi H (2007) Text book of postgraduate course of the 60th annual meeting of Japanese Association for Thoracic Surgery, pp 7–13

    Google Scholar 

  12. Bhatt DL, Chew DP, Hirsch AT, Ringleb PA, Hacke W, Topol EJ (2001) Superiority of clopidogrel versus aspirin in patients with prior cardiac surgery. Circulation 103:363–368

    Article  CAS  PubMed  Google Scholar 

  13. Halkos ME, Cooper WA, Petersen R, Puskas JD, Lattouf OM, Craver JM, Guyton RA (2006) Early administration of clopidogrel is safe after off-pump coronary artery bypass surgery. Ann Thorac Surg 81:815–819

    Article  PubMed  Google Scholar 

  14. Englberger L, Streich M, Tevaearai H, Carrel TP (2008) Different anticoagulation strategies in off-pump coronary artery bypass operations: a European survey. Interact Cardiovasc Thorac Surg 7(3):378–382

    Article  PubMed  Google Scholar 

  15. Hosokawa K, Nakajima Y, Umenai T et al (2007) Predictors of atrial fibrillation after off-pump coronary artery bypass graft surgery. Br J Anaesth 98:575–580

    Article  CAS  PubMed  Google Scholar 

  16. Fujii M, Bessho R, Ochi M et al (2012) Effect of postoperative landiolol administration for atrial fibrillation after off pump coronary artery bypass surgery. J Cardiovasc Surg (Trino) 53:369–374

    CAS  Google Scholar 

  17. Wakamatsu H, Takase S, Sato Y, Seto Y, Kurosawa H, Yokoyama H (2010) Effect of intra-operative low dose infusion of landiolol hydrochloride on post-operative atrial fibrillation after off-pump coronary artery bypass grafting. Kyobu Geka 63(9):764–768

    PubMed  Google Scholar 

  18. Ito N, Tashiro T, Morishige N et al (2010) Efficacy of propafenone hydrochloride in preventing postoperative atrial fibrillation after coronary artery bypass grafting. Heart Surg Forum 13:E223–E227

    Article  PubMed  Google Scholar 

  19. Kinoshita T, Asai T, Nishimura O et al (2010) Statin for prevention of atrial fibrillation after off-pump coronary artery bypass grafting in Japanese patients. Circ J 74:1846–1851

    Article  PubMed  Google Scholar 

  20. Peterson ED, Cowper PA, Jollis JG et al (1995) Outcomes of coronary artery bypass graft surgery in 24,461 patients aged 80 years or older. Circulation 92(Suppl):II85–II91

    Article  CAS  PubMed  Google Scholar 

  21. Williams DB, Carrillo RG, Traad EA et al (1995) Determinants of operative mortality in octogenarians undergoing coronary bypass. Ann Thorac Surg 60:1038–1043

    Article  CAS  PubMed  Google Scholar 

  22. Stamou SC, Dangas G, Dullum MKC et al (2000) Beating heart surgery in octogenarians: perioperative outcome and comparison with younger age groups. Ann Thorac Surg 69:1140–1145

    Article  CAS  PubMed  Google Scholar 

  23. Tanaka H, Narisawa T, Masuda M, KIshi D, Suzuki T (2004) Coronary artery bypass in patients 80 years and older: comparison with a younger age group. Ann Thorac Caridovasc Surg 10(2):85–89

    Google Scholar 

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Correspondence to Mitsuaki Sadahiro .

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Sadahiro, M. (2016). Patient Management OPCAB. In: Asai, T., Ochi, M., Yokoyama, H. (eds) Off-Pump Coronary Artery Bypass. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54986-4_20

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  • DOI: https://doi.org/10.1007/978-4-431-54986-4_20

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54985-7

  • Online ISBN: 978-4-431-54986-4

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