Abstract
Recent advance in endoscopic imaging technology enables the endoscopists to detect esophageal squamous cell carcinoma (ESCC) more accurately than conventional white light image (WLI) and Lugol chromoendoscopy. Especially, magnifying endoscopy and equipment-based image-enhanced endoscopy (IEE) [1] including narrow-band imaging (NBI) opened a brand new door of the endoscopic diagnostic field. Magnifying endoscopy combined with IEE can visualize the microstructure of the epithelial surface and microvasculature. Based on the morphological changes in these structures, we can make diagnosis more correctly and objectively. Therefore, in addition to the previous conventional strategy of endoscopic diagnosis, new diagnostic strategies based on morphological changes in the microvasculature and epithelial surface are now required and needed for the endoscopists.
In this chapter, we explained diagnostic strategies by practical endoscopy including detection, differential diagnosis, evaluation of depth of invasion, and histological confirmation of squamous cell carcinoma of the esophagus.
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Kaltenbach T et al (2008) American Gastroenterological Association (AGA) Institute technology assessment on image-enhanced endoscopy. Gastroenterology 134:327–340
The Japan Esophageal Society (2008) Japanese classification of esophageal cancer, 10th edn. p 57, Revised version. The Japan Esophageal Society. Tokyo, Japan
Mori M et al (1993) Lugol staining pattern and histology of esophageal lesions. Am J Gastroenterol 88:701–705
Shimizu Y et al (2008) Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes. J Gastroenterol Hepatol 23:546–550
Ishihara R et al (2009) Quantitative analysis of the color change after iodine staining for diagnosing esophageal high-grade intraepithelial neoplasia and invasive cancer. Gastrointest Endosc 69:213
Muto M et al (2000) Association of Aldehyde dehydrogenase 2 gene polymorphism with multiple esophageal dysplasia in head and neck cancer patients. Gut 47:256–261
Muto M et al (2002) Association of multiple Lugol-voiding lesions with synchronous and metachronous esophageal squamous cell carcinoma in patients with head and neck cancer. Gastrointest Endosc 56:517–521
Slaughter DP et al (1953) Field cancerization in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 6:963–968
Gono K et al (2003) Endoscopic observation of tissue by narrow band illumination. Opt Rev 10:1–5
Gono K et al (2004) Appearance of enhanced tissue feature in narrow-band endoscopic imaging. J Biomed Opt 9:568–577
Muto M et al (2004) Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites. Cancer 101:1375–1381
Muto M et al (2005) Narrow band imaging: a new diagnostic approach to visualize angiogenesis in superficial neoplasia. Clin Gastroenterol Hepatol 3:S16–S20
Inoue H et al (1997) Ultra-high magnification endoscopic observation of carcinoma in situ of the oesophagus. Dig Endosc 9:16–18
Muto M et al (2010) Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol 28:1566–1572
Takenaka R et al (2009) Narrow-band imaging provides reliable screening for esophageal malignancy in patients with head and neck cancers. Am J Gastroenterol 104:2942–2948
Kodama M, Kakegawa T (1998) Treatment of superficial cancer of the esophagus: a summary of responses to a questionnaire on superficial cancer of the esophagus. Surgery 123:432–439
Yoshida T et al (2004) Narrow-band imaging system with magnifying endoscopy for superficial esophageal lesions. Gastrointest Endosc 59:288–295
Takizawa K et al (2009) Lymph node staging in esophageal squamous cell carcinoma: a comparative study of endoscopic ultrasonography versus computed tomography. J Gastroenterol Hepatol 24:1687–1691
Hatta W et al (2011) A prospective comparative study of optical coherence tomography and EUS for tumor staging of superficial esophageal squamous cell carcinoma. Gastrointest Endosc 76:548–555
Inoue H et al (2004) In vivo observation of living cancer cells in the esophagus, stomach, and colon using catheter-type con- tact endoscope, ‘Endocytoscopy system’. Gastrointest Endosc Clin N Am 14:589–594
Inoue H et al (2006) Endoscopic in vivo evaluation of tissue atypia in the esophagus using a newly designed integrated endocytoscope: a pilot trial. Endoscopy 38:891–895
Kumagai Y et al (2010) Endocytoscopic observation of esophageal squamous cell carcinoma. Dig Endosc 22:10–16
Fujishiro M et al (2007) Potential and present limitation of endocytoscopy in the diagnosis of esophageal squamous-cell carcinoma: a multicenter ex vivo pilot study. Gastrointest Endosc 66:551–555
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Muto, M. (2015). Endoscopic Diagnosis of Squamous Cell Carcinoma of the Esophagus. In: Ando, N. (eds) Esophageal Squamous Cell Carcinoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54977-2_4
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DOI: https://doi.org/10.1007/978-4-431-54977-2_4
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