Abstract
When the temperature of a dilute polymer solution is changed gradually far below the Θ point, the conformation of individual polymer chains changes from a random coil to a compact globular state (coil-globule transition), followed by intermolecular aggregation owing to phase separation. In this chapter, the coil-globule transition and the aggregation behavior in dilute solutions of typical neutral synthetic homopolymers, poly(N-isopropylacrylamide) (PNIPAM) and poly(methyl methacrylate) (PMMA), are reviewed, and some rheological aspects of the kinetics of chain collapse and chain aggregation are demonstrated. The applicability of the rheological concepts derived from the aggregation behavior of synthetic homopolymers to that of intrinsically disordered proteins (IDPs) is considered.
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Notes
- 1.
An aqueous solution of water-soluble polymers shows an LCST-type behavior in many cases. However, a group of water-soluble polymers showing a UCST-type behavior has attracted much attention in recent years [30].
- 2.
Note that phase diagrams of some polymer-solvent systems show both UCST- and LCST-type behaviors [31].
- 3.
References
Grosberg AY, Khokhlov AR (1994) Statistical physics of macromolecules. AIP Press, New York
Flory PJ (1952) Principles of polymer chemistry. Cornell University Press, Ithaca
Hirokawa Y, Tanaka T (1984) J Chem Phys 81:6379
Gil ES, Hudson SM (2004) Prog Polym Sci 29:1173–1222
Hoffman AS, Stayton PS (2004) Macromol Symp 207:139–151
Kikuchi A, Okano T (2002) Adv Drug Deliv Rev 54:53–77
Clark AH (1998) Gelation of globular proteins. In: Hill SE, Ledward DA, Mitchell JR (eds) Functional properties of food macromolecules. Aspen Publishers, Gaithersburg
Wang W (2005) Int J Pharm 289:1–30
Baysal BM, Karasz FE (2003) Macromol Theory Simul 12:627
Aseyev VO, Tenhu H, Winnik FM (2006) Adv Polym Sci 196:1–85
Pappu RV, Wang X, Vitalis A et al (2008) Arch Biochem Biophys 469:132–141
Tanford C (1966) Physical chemistry of macromolecules. Wiley, New York
Zhang G, Wu C (2005) Adv Polym Sci 195:1
Nakata M (1995) Phys Rev E 51:5770
Maki Y, Sasaki N, Nakata M (2004) Macromolecules 37:5703–5709
Nakata M, Nakagawa T (1997) Phys Rev E 56:3338
Nakamura Y, Sasaki N, Nakata M (2001) Macromolecules 34:5992–6002
Maki Y, Dobashi T, Nakata M (2007) J Chem Phys 126:134901
Nakata M, Nakagawa T (1999) J Chem Phys 110:2703
Nakamura Y, Sasaki N, Nakata M (2003) J Chem Phys 118:3861
Maki Y, Dobashi T (2012) Kobunshi Ronbunshu 69:373–381
Nakata M, Nakamura Y, Maki Y (2004) Macromolecules 37:4917
Nakata M, Nakamura Y, Sasaki N et al (2012) Phys Rev E 85:021802
Nakata M, Nakagawa T, Nakamura Y et al (1999) J Chem Phys 110:2711
Nakagawa T, Nakamura Y, Sasaki N et al (2001) Phys Rev E 63:031803
Maki Y, Dobashi T, Nakata M (2008) Phys Rev E 78:041802
Nakamura Y, Nakagawa T, Sasaki N et al (2001) Macromolecules 34:5984–5991
Nakamura Y, Sasaki N, Nakata M (2002) Macromolecules 35:1365–1372
Nakata M, Nakamura Y, Sasaki N (2007) Phys Rev E 76:041805
Seuring J, Agarwal S (2012) Macromol Rapid Commun 33:1898–1920
Koningsveld R, Stockmayer WH, Nies E (2001) Polymer phase diagrams, a text book. Oxford University Press, Oxford
Stockmayer WH (1960) Makromol Chem 35:54
Birshtein TM, Pryamitsyn VA (1991) Macromolecules 24:1554–1560
Grosberg AY, Kuznetsov DV (1992) Macromolecules 25:1970–1979
Grosberg AY, Kuznetsov DV (1992) Macromolecules 25:1996–2003
Grosberg AY, Kuznetsov DV (1992) Macromolecules 25:1980–1990
Lifshitz IM, Grosberg AY, Khokhlov AR (1978) Rev Mod Phys 50:683–713
Sun ST, Nishio I, Swislow G et al (1980) J Chem Phys 73:5971–5975
Park IH, Wang QW, Chu B (1987) Macromolecules 20:1965–1975
Kubota K, Fujishige S, Ando I (1990) J Phys Chem 94:5154–5158
Wu C, Zhou S (1995) Macromolecules 28:8381–8387
Wang X, Qiu X, Wu C (1998) Macromolecules 31:2972–2976
Burchard W (1996) Combined static and dynamic light scattering. In: Brown W (ed) Light scattering: principles and development. Clarendon, New York
Okada Y, Tanaka F (2005) Macromolecules 38:4465–4471
Tanaka F, Koga T, Kojima H et al (2009) Macromolecules 42:1321–1330
Witelski TP, Grosberg AY, Tanaka T (1998) J Chem Phys 108:9144–9149
Abe F, Einaga Y, Yamakawa H (1995) Macromolecules 28:694
Yamakawa H, Abe F, Einaga Y (1994) Macromolecules 27:3272
Baysal BM, Kayaman N (1998) J Chem Phys 109:8701–8707
Dogan M, Kuntman A (2000) Polym Int 49:1648–1652
Kayaman N, Gürel EE, Baysal BM et al (2000) Polymer 41:1461–1468
Kayaman N, Gürel EE, Baysal M et al (1999) Macromolecules 32:8399–8403
de Gennes PG (1985) J Phys Lett 46:L-639
Grosberg AY, Nechaev SK, Shakhnovich EI (1988) J Phys (France) 49:2095
Buguin A, Brochart-Wyart F, de Gennes PG (1996) C R Acad Sci Ser IIb Mec Phys Chim Astron 322:741
Klushin LI (1998) J Chem Phys 108:7917
Halperin PM, Goldbart PM (2000) Phys Rev E 61:565
Byrne A, Kiernan P, Green D et al (1995) J Chem Phys 102:573
Kuznetsov YA, Timoshenko EG, Dawson KA (1995) J Chem Phys 103:4807
Kuznetsov YA, Timoshenko EG, Dawson KA (1996) J Chem Phys 104:3338
Abrams CF, Lee N-K, Obukhov SP (2002) Europhys Lett 59:391–397
Frisch T, Verga A (2002) Phys Rev E 66:041807
Kikuchi N, Ryder JF, Poooley CM et al (2005) Phys Rev E 71:061804
Kamata K, Araki T, Tanaka H (2009) Phys Rev Lett 102:108303
Chu B, Ying Q, Grosberg AY (1995) Macromolecules 28:180–189
Xu J, Zhu X, Luo S et al (2006) Phys Rev Lett 96:027802
Zhang GZ, Wu C (2001) Phys Rev Lett 86:822
Ye X, Lu Y, Shen L et al (2007) Macromolecules 40:4750–4752
Mansfield ML (2007) J Chem Phys 127:244902
Rabin Y, Grosberg AY, Tanaka T (1995) Europhys Lett 32:505
Lee N-K, Abrams CF, Johner A et al (2003) Phys Rev Lett 90:225504
Lee N-K, Abrams CF, Johner A et al (2004) Macromolecules 37:4917
Chu B, Ying Q (1996) Macromolecules 29:1824–1826
Heskins M, Guillet JE (1968) J Macromol Sci Chem A2:1441
Schild HG, Tirrell DA (1990) J Phys Chem 94:4352
Fujishige S, Kubota K, Ando I (1989) J Phys Chem 93:3311–3313
Van Durme K, Van Assche G, Van Mele B (2004) Macromolecules 37:9596
Tong Z, Zeng F, Zheng X et al (1999) Macromolecules 32:4488–4490
Xia Y, Yin X, Burke NAD, Stöver HDH (2005) Macromolecules 38:5937–5943
Kawaguchi T, Kojima Y, Osa M et al (2008) Polym J 40:455
Kawaguchi T, Kojima Y, Osa M et al (2008) Polym J 40:528
Katsumoto Y, Kubosaki N (2008) Macromolecules 41:5955–5956
Katsumoto Y, Kubosaki N, Miyata T (2010) J Chem Phys B 114:1044–1045
Nishi K, Hiroi T, Hashimoto K et al (2013) Macromolecules 46:6225–6232
McPhee W, Tam KC, Pelton R (1993) J Colloid Interface Sci 156:24
Gorelov AV, Du Chesne A, Dawson KA (1997) Phys A 240:443–452
Timoshenko EG, Kuznetsov YA (2001) Europhys Lett 53:322–327
Aseyev V, Hietala S, Laukkanen A et al (2005) Polymer 46:7118–7131
von Smoluchowski M (1916) Phys Z 17:585
von Smoluchowski M (1917) Z Phys Chem Stoechiom Verwandtschafts 92:129
Chan K, Pelton R, Zhang J (1999) Langmuir 15:4018–4020
Tanaka H (1992) Macromolecules 25:6377–6380
Tanaka H (2000) J Phys Condens Matter 12:R207–R264
Chuang J, Grosberg AY, Tanaka T (2000) J Chem Phys 112:6434
Kujawa P, Aseyev V, Tenhu H et al (2006) Macromolecules 39:7686–9693
Pamies R, Zhu K, Kjøniksen A-L et al (2009) Polym Bull 62:487–502
Kawaguchi T, Kobayashi K, Osa M et al (2009) J Phys Chem B 113:5440
Vicsek T (1989) Fractal growth phenomena. World Scientific, Singapore
Chen W, Zhao Y, Jiang Y et al (2004) Chem Phys Chem 5:1745–1749
Nicolai T, Durand D (2007) Curr Opin Colloid Interface Sci 12:23–28
Uversky VN, Fink AL (2004) Biochim Biophys Acta 1698:131–153
Crick SL, Jayaraman M, Frieden C et al (2006) Proc Natl Acad Sci 103:16764–16769
Digambaranath JL, Campbell TV, Chung A et al (2010) Proteins 79:1427–1440
Nekooki-Machida Y, Kurosawa M, Nukina N et al (2009) Proc Natl Acad Sci 24:9679–9684
Chen S, Berthelier V, Yang W et al (2001) J Mol Biol 311:173–182
Chen S, Ferrone FA, Wetzel R (2002) Proc Natl Acad Sci 99:11884–11889
Walters RH, Murphy RM (2009) J Mol Biol 393:978–992
Vitalis A, Paapu RV (2011) Biophys Chem 159:14–23
Masino L, Kelly G, Leonard K et al (2002) FEBS Lett 513:267–272
Khare SD, Ding F, Gwanmesia KN et al (2005) PLoS Comput Biol 1:230–235
Vitalis A, Wang X, Pappu RV (2007) Biophys J 93:1923–1937
Vitalis A, Wang X, Pappu RV (2008) J Mol Biol 384:279–297
Grosberg AY, Kuznetsov DV (1992) J Phys II 2:1327
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Maki, Y. (2015). Rheological Aspects of Conformational Change and Molecular Aggregation of Macromolecules. In: Kita, R., Dobashi, T. (eds) Nano/Micro Science and Technology in Biorheology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54886-7_2
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DOI: https://doi.org/10.1007/978-4-431-54886-7_2
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