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Liver Cancer (Hepatocellular Carcinoma; HCC)

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Stereotactic Body Radiation Therapy
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Abstract

Although resection remains the first choice of treatment for hepatocellular carcinoma (HCC), the use of stereotactic body radiotherapy (SBRT) has rapidly increased over the past decade. The results of local control were excellent, indicating the possibility of achieving local control for HCC, including advanced cases, without severe adverse effects. In the future, more prospective studies will be needed to establish evidence of SBRT.

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References

  1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. Cancer J Clin. 2011;61:69–90.

    Article  Google Scholar 

  2. Buti M, San Miguel R, Brosa M, et al. Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C. J Hepatol. 2005;42:639–45.

    Article  PubMed  Google Scholar 

  3. European Association for the Study of the Liver and European Organisation for Research and Treatment of Cancer. EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56:908–43.

    Google Scholar 

  4. Klein J, Dawson LA. Hepatocellular carcinoma radiation therapy: review of evidence and future opportunities. Int J Radiat Oncol Biol Phys. 2013;87:22–32.

    Article  PubMed  Google Scholar 

  5. Thomas MB, Jaffe D, Choti MM, et al. Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting. J Clin Oncol. 2010;28:3994–4005.

    Article  PubMed Central  PubMed  Google Scholar 

  6. Kudo M, Arii S, Ikai I, et al. Report of the 18th follow-up survey of primary liver cancer in Japan. Osaka-Sayama: Liver Cancer Study Group of Japan; 2009.

    Google Scholar 

  7. Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693–9.

    Article  CAS  PubMed  Google Scholar 

  8. Choi E, Rogers E, Ahmad S, et al. Hepatobiliary cancers. In: Feig BW, Berger DH, Fuhrman GM, editors. The M. D. Anderson surgical oncology handbook. Philadelphia: Lippincott Williams &Wilkins; 2006.

    Google Scholar 

  9. Shiina S, Teratani T, Obi S, et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology. 2005;129:122–30.

    Article  PubMed  Google Scholar 

  10. Goldberg SN, Grassi CJ, Cardella JF, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria. Radiology. 2005;235:728–39.

    Article  PubMed Central  PubMed  Google Scholar 

  11. Liu JG, Wang YJ, Du Z. RFA in the treatment of small HCC: a meta-analysis. World J Gastroenterol. 2010;16:3450–6.

    Article  PubMed Central  PubMed  Google Scholar 

  12. Miyayama S, Matsui O, Yamashiro M, et al. Ultraselective transcatheter arterial chemoembolization with a 2-f tip microcatheter for small hepatocellular carcinomas: relationship between local tumor recurrence and visualization of portal vein with iodized oil. J Vasc Interv Radiol. 2007;18:365–76.

    Article  PubMed  Google Scholar 

  13. Takayasu K, Arii S, Kudo M, et al. Superselective transarterial chemoembolization for hepatocellular carcinoma: validation of treatment algorithm proposed by Japanese guidelines. J Hepatol. 2012;56:886–92.

    Article  PubMed  Google Scholar 

  14. Arii S, Yamaoka Y, Futagawa S, et al. Results of surgical and nonsurgical treatment for small sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan: The Liver Cancer Study Group of Japan. Hepatology. 2000;32:1224–9.

    Article  CAS  PubMed  Google Scholar 

  15. Bujold A, Massey CA, Kim JJ, et al. Sequential Phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma. J Clin Oncol. Published ahead of print.

    Google Scholar 

  16. Andolino DL, Johnson CS, Maluccio M, et al. Stereotactic body radiotherapy for primary hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2011;81:e447–53.

    Article  PubMed  Google Scholar 

  17. Kwon JH, Bae SH, Kim JY, et al. Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection: stereotactic radiotherapy for liver cancer. BMC Cancer. 2010;10:475.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Kang JK, Kim MS, Cho CK, et al. Stereotactic body radiation therapy for inoperable hepatocellular carcinoma as a local salvage treatment after incomplete transarterial chemoembolization. Cancer. 2012;118:5424–31.

    Article  PubMed  Google Scholar 

  19. Sanuki N, Takeda A, Oku Y, et al. Stereotactic body radiotherapy for small hepatocellular carcinoma: a retrospective outcome analysis in 185 patients. Acta Oncol. Published ahead of print.

    Google Scholar 

  20. Dawson LA. Overview: where does radiation therapy fit in the spectrum of liver cancer local – regional therapies? Semin Radiat Oncol. 2011;21:241–6.

    Article  PubMed  Google Scholar 

  21. Honda Y, Kimura T, Aikata H, et al. Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma. J Gastroenterol Hepatol. 2013;28:530–6.

    Article  PubMed  Google Scholar 

  22. Sempoux C, Horsmans Y, Geubel A, et al. Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event. Hepatology. 1997;26:128–34.

    Article  CAS  PubMed  Google Scholar 

  23. Pan CC, Kavanagh BD, Dawson LA, et al. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys. 2010;76:S94–100.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Guha C, Kavanagh BD. Hepatic radiation toxicity: avoidance and amelioration. Semin Radiat Oncol. 2011;21:256–63.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Lee IJ, Seong J, Shin SJ, et al. Radiotherapeutic parameters predictive of liver complications induced by liver tumor radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:154–8.

    Article  PubMed  Google Scholar 

  26. Son SH, Choi BO, Ryu MR, et al. Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication. Int J Radiat Oncol Biol Phys. 2010;78:1073–80.

    Article  PubMed  Google Scholar 

  27. Bae SH, Kim MS, Cho CK, et al. Predictor of severe gastroduodenal toxicity after stereotactic body radiotherapy for abdominopelvic malignancies. Int J Radiat Oncol Biol Phys. 2012;84:e469–74.

    Article  PubMed  Google Scholar 

  28. Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010;30:52–60.

    Article  CAS  PubMed  Google Scholar 

  29. Kimura T, Takahashi S, Kenjo M, et al. Dynamic computed tomography appearance of tumor response after stereotactic radiation therapy for hepatocellular carcinoma: how should we evaluate treatment effects? Hepatol Res. 2013;43:717–27.

    Article  CAS  PubMed  Google Scholar 

  30. Herfarth KK, Hof H, Bahner ML, et al. Assessment of focal liver reaction by multiphasic CR after stereotactic single-dose radiotherapy of liver tumors. Int J Radiat Oncol Biol Phys. 2003;57:444–51.

    Article  PubMed  Google Scholar 

  31. Sanuki-Fujimoto N, Takeda A, Ohashi T, et al. CT evaluations of focal liver reactions following stereotactic body radiotherapy for small hepatocellular carcinoma with cirrhosis: relationship between imaging appearance and baseline liver function. Br J Radiol. 2010;83:1063–71.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Willemart S, Nicaise N, Struyven J, et al. Acute radiation-induced hepatic injury: evaluation by triphasic contrast enhanced helical CT. Br J Radiol. 2000;73:544–6.

    Article  CAS  PubMed  Google Scholar 

  33. Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging. 2009;30:1042–637.

    Article  PubMed  Google Scholar 

  34. Nakamura Y, Kimura T, Higaki T, et al. Imaging findings of liver parenchyma after stereotactic body radiation therapy for hepatocellular carcinoma: evaluation by gadoxetate disodium-enhanced hepatic MRI. Radiology. Abstract.

    Google Scholar 

  35. Sanuki N, Takeda A, Oku Y, et al. Threshold doses for focal liver reaction after stereotactic ablative body radiation therapy for small hepatocellular carcinoma depend on liver function: evaluation on magnetic resonance imaging with Gd-EOB-DTPA. Int J Radiat Oncol Biol Phys. 2014;88:306–11.

    Article  PubMed  Google Scholar 

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Correspondence to Tomoki Kimura .

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Kimura, T. (2015). Liver Cancer (Hepatocellular Carcinoma; HCC). In: Nagata, Y. (eds) Stereotactic Body Radiation Therapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54883-6_14

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  • DOI: https://doi.org/10.1007/978-4-431-54883-6_14

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54882-9

  • Online ISBN: 978-4-431-54883-6

  • eBook Packages: MedicineMedicine (R0)

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