Abstract
Although resection remains the first choice of treatment for hepatocellular carcinoma (HCC), the use of stereotactic body radiotherapy (SBRT) has rapidly increased over the past decade. The results of local control were excellent, indicating the possibility of achieving local control for HCC, including advanced cases, without severe adverse effects. In the future, more prospective studies will be needed to establish evidence of SBRT.
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References
Jemal A, Bray F, Center MM, et al. Global cancer statistics. Cancer J Clin. 2011;61:69–90.
Buti M, San Miguel R, Brosa M, et al. Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C. J Hepatol. 2005;42:639–45.
European Association for the Study of the Liver and European Organisation for Research and Treatment of Cancer. EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56:908–43.
Klein J, Dawson LA. Hepatocellular carcinoma radiation therapy: review of evidence and future opportunities. Int J Radiat Oncol Biol Phys. 2013;87:22–32.
Thomas MB, Jaffe D, Choti MM, et al. Hepatocellular carcinoma: consensus recommendations of the National Cancer Institute Clinical Trials Planning Meeting. J Clin Oncol. 2010;28:3994–4005.
Kudo M, Arii S, Ikai I, et al. Report of the 18th follow-up survey of primary liver cancer in Japan. Osaka-Sayama: Liver Cancer Study Group of Japan; 2009.
Mazzaferro V, Regalia E, Doci R, et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693–9.
Choi E, Rogers E, Ahmad S, et al. Hepatobiliary cancers. In: Feig BW, Berger DH, Fuhrman GM, editors. The M. D. Anderson surgical oncology handbook. Philadelphia: Lippincott Williams &Wilkins; 2006.
Shiina S, Teratani T, Obi S, et al. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology. 2005;129:122–30.
Goldberg SN, Grassi CJ, Cardella JF, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria. Radiology. 2005;235:728–39.
Liu JG, Wang YJ, Du Z. RFA in the treatment of small HCC: a meta-analysis. World J Gastroenterol. 2010;16:3450–6.
Miyayama S, Matsui O, Yamashiro M, et al. Ultraselective transcatheter arterial chemoembolization with a 2-f tip microcatheter for small hepatocellular carcinomas: relationship between local tumor recurrence and visualization of portal vein with iodized oil. J Vasc Interv Radiol. 2007;18:365–76.
Takayasu K, Arii S, Kudo M, et al. Superselective transarterial chemoembolization for hepatocellular carcinoma: validation of treatment algorithm proposed by Japanese guidelines. J Hepatol. 2012;56:886–92.
Arii S, Yamaoka Y, Futagawa S, et al. Results of surgical and nonsurgical treatment for small sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan: The Liver Cancer Study Group of Japan. Hepatology. 2000;32:1224–9.
Bujold A, Massey CA, Kim JJ, et al. Sequential Phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma. J Clin Oncol. Published ahead of print.
Andolino DL, Johnson CS, Maluccio M, et al. Stereotactic body radiotherapy for primary hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2011;81:e447–53.
Kwon JH, Bae SH, Kim JY, et al. Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection: stereotactic radiotherapy for liver cancer. BMC Cancer. 2010;10:475.
Kang JK, Kim MS, Cho CK, et al. Stereotactic body radiation therapy for inoperable hepatocellular carcinoma as a local salvage treatment after incomplete transarterial chemoembolization. Cancer. 2012;118:5424–31.
Sanuki N, Takeda A, Oku Y, et al. Stereotactic body radiotherapy for small hepatocellular carcinoma: a retrospective outcome analysis in 185 patients. Acta Oncol. Published ahead of print.
Dawson LA. Overview: where does radiation therapy fit in the spectrum of liver cancer local – regional therapies? Semin Radiat Oncol. 2011;21:241–6.
Honda Y, Kimura T, Aikata H, et al. Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinoma. J Gastroenterol Hepatol. 2013;28:530–6.
Sempoux C, Horsmans Y, Geubel A, et al. Severe radiation-induced liver disease following localized radiation therapy for biliopancreatic carcinoma: activation of hepatic stellate cells as an early event. Hepatology. 1997;26:128–34.
Pan CC, Kavanagh BD, Dawson LA, et al. Radiation-associated liver injury. Int J Radiat Oncol Biol Phys. 2010;76:S94–100.
Guha C, Kavanagh BD. Hepatic radiation toxicity: avoidance and amelioration. Semin Radiat Oncol. 2011;21:256–63.
Lee IJ, Seong J, Shin SJ, et al. Radiotherapeutic parameters predictive of liver complications induced by liver tumor radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73:154–8.
Son SH, Choi BO, Ryu MR, et al. Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication. Int J Radiat Oncol Biol Phys. 2010;78:1073–80.
Bae SH, Kim MS, Cho CK, et al. Predictor of severe gastroduodenal toxicity after stereotactic body radiotherapy for abdominopelvic malignancies. Int J Radiat Oncol Biol Phys. 2012;84:e469–74.
Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010;30:52–60.
Kimura T, Takahashi S, Kenjo M, et al. Dynamic computed tomography appearance of tumor response after stereotactic radiation therapy for hepatocellular carcinoma: how should we evaluate treatment effects? Hepatol Res. 2013;43:717–27.
Herfarth KK, Hof H, Bahner ML, et al. Assessment of focal liver reaction by multiphasic CR after stereotactic single-dose radiotherapy of liver tumors. Int J Radiat Oncol Biol Phys. 2003;57:444–51.
Sanuki-Fujimoto N, Takeda A, Ohashi T, et al. CT evaluations of focal liver reactions following stereotactic body radiotherapy for small hepatocellular carcinoma with cirrhosis: relationship between imaging appearance and baseline liver function. Br J Radiol. 2010;83:1063–71.
Willemart S, Nicaise N, Struyven J, et al. Acute radiation-induced hepatic injury: evaluation by triphasic contrast enhanced helical CT. Br J Radiol. 2000;73:544–6.
Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? J Magn Reson Imaging. 2009;30:1042–637.
Nakamura Y, Kimura T, Higaki T, et al. Imaging findings of liver parenchyma after stereotactic body radiation therapy for hepatocellular carcinoma: evaluation by gadoxetate disodium-enhanced hepatic MRI. Radiology. Abstract.
Sanuki N, Takeda A, Oku Y, et al. Threshold doses for focal liver reaction after stereotactic ablative body radiation therapy for small hepatocellular carcinoma depend on liver function: evaluation on magnetic resonance imaging with Gd-EOB-DTPA. Int J Radiat Oncol Biol Phys. 2014;88:306–11.
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Kimura, T. (2015). Liver Cancer (Hepatocellular Carcinoma; HCC). In: Nagata, Y. (eds) Stereotactic Body Radiation Therapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54883-6_14
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DOI: https://doi.org/10.1007/978-4-431-54883-6_14
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54882-9
Online ISBN: 978-4-431-54883-6
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