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Innovation of Vascular Engineering by Mechanomedicine

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Vascular Engineering

Abstract

This article describes how physical forces contribute to development, physiology, and pathology of vascular cells, focusing on endothelial cells and vascular smooth muscle cells. Based on these basic understandings of the mechanobiology, we discuss mechanomedicine, an application of the mechanobiology to medicine. Basic knowledge about cellular responses, such as cellular signal transduction pathway, gene expression, and cytoskeletal remodeling, to mechanical stimuli is important for understanding the pathology of vascular diseases including atherosclerosis. Introducing the knowledge of the vascular mechanobiology will not only contribute to the development of regenerative medicine using pluripotent stem cells but also provide a way to prevent diseases caused by thromboembolisms, such as myocardial and cerebral infarctions.

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Authors and Affiliations

  1. Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, 700-8525, Okayama, Japan

    Ken Takahashi & Keiji Naruse

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  1. Ken Takahashi
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  2. Keiji Naruse
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Correspondence to Keiji Naruse .

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Editors and Affiliations

  1. Waseda University, Tokyo, Tokyo, Japan

    Kazuo Tanishita

  2. The University of Tokyo, Tokyo, Tokyo, Japan

    Kimiko Yamamoto

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Takahashi, K., Naruse, K. (2016). Innovation of Vascular Engineering by Mechanomedicine. In: Tanishita, K., Yamamoto, K. (eds) Vascular Engineering. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54801-0_15

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  • DOI: https://doi.org/10.1007/978-4-431-54801-0_15

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