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Diagnosing Vascular Variability Disorders and Vascular Variability Syndromes

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Chronomics and Continuous Ambulatory Blood Pressure Monitoring

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Abstract

Currently, 24-hour monitoring of blood pressure (BP) by ambulatory functioning devices is a gold standard, reserved for special cases of high BP, left uninterpreted in terms of its time structure. General reliance upon a single measurement (or a single 24-hour profile) of BP, however, has been dubbed “flying blind.” Long-term BP monitoring, analyzed time-structurally (chronomically, from chronome = time structure), detects physiological-physical interactions. The chronobiological and chronomicinterpretation of ambulatory blood pressure monitoring (C-ABPM) records in the light of time-specified reference values derived from healthy peers matched by gender and age identifies vascular variability anomalies (VVAs) for an assessment of cardio-cerebro-reno-vascular disease risk. Even within the conventionally accepted normal range, VVAs have been associated with a statistically significant increase in risk. Long-term C-ABPM records help to “know ourselves,” serving for relief of psychological and other strain once transient VVAs are linked to the source of a load, prompting adjustment of one’s lifestyle for strain reduction.

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Authors and Affiliations

  1. Department of Chronomics & Gerontology, Tokyo Women’s Medical University Medical Center East, Arakawa-ku, Tokyo, Japan

    Kuniaki Otsuka

  2. Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA

    Germaine Cornelissen & Franz Halberg

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  3. Franz Halberg
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Otsuka, K., Cornelissen, G., Halberg, F. (2016). Diagnosing Vascular Variability Disorders and Vascular Variability Syndromes. In: Chronomics and Continuous Ambulatory Blood Pressure Monitoring. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54631-3_16

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