Abstract
In the chemical industry, there is a need for innovative manufacturing processes that are not dependent on fossil resources and have reduced environmental impact. Bioprocesses are advantageous as environmentally friendly or green processes and are also superior to chemical processes in terms of reaction specificity and substrate selectivity. However, the aqueous reaction fields used in bioprocesses are not suitable for the conversion, reaction, or production of the hydrophobic materials that account for the majority of chemicals. Therefore, to enable more general use of chemical production technologies employing bioprocesses, the author has screened for organic solvent-tolerant microorganisms, that is, microorganisms with the ability to maintain cellular structure in organic solvents, and created biocatalysts using such microorganisms as host cells.
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References
Aono R, Nakajima H (1997) Tolerance of E. coli for hydrophobic organic solvents. Protein Nucleic Acid Enzyme 42(15):2532–2541 (in Japanese)
Aono R et al (1994) Mapping of organic solvent tolerance gene ostA in Escherichia coli K12. Biosci Biotechnol Biochem 58:1231–1235
Fujita K et al (2004) Comprehensive gene expression analysis of the response to straight-chain alcohols in Saccharomyces cerevisiae using cDNA microarray. J Appl Microbiol 97:57–67
Fujita K et al (2006) The cell structural properties of Kocuria rhizophila for aliphatic alcohol exposure. Enzyme Microb Technol 39(3):511–551
Matsuda S (2004) Screening of nitrilases showing tolerance against organic solvent. Proc Soc Biotech Jpn 113 (in Japanese)
Matsuyama A, Kobayashi Y, Nagasawa T (2004) Achieving more general use of green bioprocesses using the “assembly technique”. Biosci Industry 62(1):23–26 (in Japanese)
Salter GJ et al (1995) Solvent selection for whole cell biotransformation in organic media. Crit Rev Biotechnol 15:139–177
Weber FJ, de Bont JA (1996) Adaptation mechanisms of microorganisms to the toxic effects of organic solvents on membranes. Biochim Biophys Acta 1286(3):225–245
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Matsuyama, A. (2014). Use of Organic Solvent-Tolerant Microorganisms in Bioconversion. In: Anazawa, H., Shimizu, S. (eds) Microbial Production. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54607-8_12
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DOI: https://doi.org/10.1007/978-4-431-54607-8_12
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Online ISBN: 978-4-431-54607-8
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