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Neuroanesthesia and Cerebrospinal Protection pp 63–70Cite as

Mitochondrial Physiology and Cerebrospinal Protection

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Abstract

Mitochondria maintain their numbers by the fusion and fission of preexisting mitochondria. Continuous mitochondrial fusion mixes the compartments, whereas fission segregates morphologically and functionally damaged mitochondria. This changing of their shape allows mitochondria to control the life and death processes of cells, such as apoptosis, the maintenance of cellular homeostasis, and ultimately the processes that occur in neurological disorders and metabolic diseases. GTPase family proteins and their regulators modulate the fusion/fission events, and a type of autophagy known as mitophagy removes damaged mitochondria. Although the molecular mechanistic effects of anesthetics on mitochondria are not yet clear, an enhanced understanding of this knowledge will be useful for the establishment of therapeutic approaches.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Tokyo Medical University, Tokyo, Japan

    Morika Suzuki

  2. Department of Neurophysiology, Tokyo Medical University, 6-1-1 Shinjuku, Tokyo, 160-8402, Japan

    Hiroki Kato & Naomi Hachiya

Authors
  1. Morika Suzuki
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  2. Hiroki Kato
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  3. Naomi Hachiya
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Corresponding author

Correspondence to Naomi Hachiya .

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Editors and Affiliations

  1. Tokyo Medical University, Tokyo, Japan

    Hiroyuki Uchino

  2. Kurume University, Fukuoka, Fukuoka, Japan

    Kazuo Ushijima

  3. Tokyo Medical University Hachioji Medical Center, Tokyo, Tokyo, Japan

    Yukio Ikeda

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Suzuki, M., Kato, H., Hachiya, N. (2015). Mitochondrial Physiology and Cerebrospinal Protection. In: Uchino, H., Ushijima, K., Ikeda, Y. (eds) Neuroanesthesia and Cerebrospinal Protection. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54490-6_6

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  • DOI: https://doi.org/10.1007/978-4-431-54490-6_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54489-0

  • Online ISBN: 978-4-431-54490-6

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