Skip to main content
SpringerLink
Log in

DCD for Lung Transplantation

  • Chapter
  • First Online:
Book cover Marginal Donors

  • 618 Accesses

Abstract

Lung transplantation has been performed as a well-accepted therapy for patients with various end-stage lung diseases [1]. Nonetheless, the wide spread of lung transplantation is limited by the donor shortage resulting in increasing number of deaths on waiting lists [2, 3].

Historically, the first attempts of most of solid organ transplants were from donation after cardiac death donor (DCD)/non-heart-beating donor (NHBD) [4, 5]. Since the introduction of brain death criteria, organs have been retrieved from brain-dead (heart-beating) donors. However, as a result of increasing donor shortage, there is now a renewed interest in DCD (NHBD) lung transplantation [6, 7]. DCD (NHBD) is expected to become the major source of organ supply in countries especially where the concept of brain death is not widely accepted by the public.

This chapter aims to describe the relevant published experimental evidences and recent clinical experiences with lung transplantation from DCD (NHBD).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Meyers BF, Lynch J, Trulock EP, Guthrie TJ, Cooper JD, Patterson GA. Lung transplantation: a decade of experience. Ann Surg. 1999;230:362–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Oto T, et al. Registry of the Japanese society of lung and heart-lung transplantation: the official Japanese lung transplantation report 2012. Gen Thorac Cardiovasc Surg. 2013;61(4):208–11.

    Article  PubMed  Google Scholar 

  3. Sung RS, Galloway J, Tuttle-Newhall JE, Tuttle-Newhall JE, Mone T, Laeng R, et al. Organ donation and utilization in the United States, 1997–2006. Am J Transplant. 2008;8:922–34.

    Article  CAS  PubMed  Google Scholar 

  4. Kootstra G, Kievit J, Nederstigt A. Organ donors: heartbeating and non-heartbeating. World J Surg. 2002;26:181–4.

    Article  PubMed  Google Scholar 

  5. Hardy JD, Webb WR, Dalton Jr ML, Walker Jr GR. Lung homotransplantations in man. JAMA. 1963;186:1065–74.

    Article  CAS  PubMed  Google Scholar 

  6. Love RB, Stringham JC, Chomiak PN. Successful lung transplantation using a non-heart-beating donor. J Heart Lung Transplant. 1995;14:S88 (abstr).

    Google Scholar 

  7. Steen S, Sjőberg T, Pierre L, Liao Q, Eriksson L, Algotsson L. Transplantation of lungs from a non-heart-beating donor. Lancet. 2001;357:825–9.

    Article  CAS  PubMed  Google Scholar 

  8. Kootstra G, Daemen JH, Oomen AP. Categories of non-heart-beating donors. Transplant Proc. 1995;27:2893–4.

    CAS  PubMed  Google Scholar 

  9. Steen S, et al. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg. 2007;83:2191–4.

    Article  PubMed  Google Scholar 

  10. Cypel M, Yeung JC, Keshavjee S. Novel approaches to expanding the lung donor pool: donation after cardiac death and ex vivo conditioning. Clin Chest Med. 2011;32:233–44.

    Article  PubMed  Google Scholar 

  11. de Antonio DG, et al. Results of clinical lung transplant from uncontrolled non-heart-beating donors. J Heart Lung Transplant. 2007;26:529–34.

    Article  PubMed  Google Scholar 

  12. Oto T, et al. A practical approach to clinical lung transplantation from a Maastricht category III donor with cardiac death. J Heart Lung Transplant. 2007;26:196–9.

    Article  PubMed  Google Scholar 

  13. Snell GI, et al. Early lung transplantation success utilizing controlled donation after cardiac death donors. Am J Transplant. 2008;8:1282–9.

    Article  CAS  PubMed  Google Scholar 

  14. Orens JB, Boehler A, de Perrot M, Estenne M, Glanville AR, Keshavjee S, et al. A review of lung transplant donor acceptability criteria. J Heart Lung Transplant. 2003;22:1183–200.

    Article  PubMed  Google Scholar 

  15. Steen S, Ingemansson R, Budrikis A, Bolys R, Roscher R, Sjőberg T. Successful transplantation of lungs topically cooled in the non-heart-beating donor for 6 hours. Ann Thorac Surg. 1997;63:345–51.

    Article  CAS  PubMed  Google Scholar 

  16. Oto T, Excell L, Griffiths AP, Levvey BJ, Snell GI. The implications of pulmonary embolism in a multiorgan donor for subsequent pulmonary, renal, and cardiac transplantation. J Heart Lung Transplant. 2008;27:78–85.

    Article  PubMed  Google Scholar 

  17. Oto T, Rabinov M, Griffiths AP, et al. Unexpected donor pulmonary embolism affects early outcomes after lung transplantation: a major mechanism of primary graft failure? J Thorac Cardiovasc Surg. 2005;130:1446.

    PubMed  Google Scholar 

  18. Levvey BJ, Westall GP, Kotsimbos T, Williams TJ, Snell GI. Definitions of warm ischemic time when using controlled donation after cardiac death lung donors. Transplantation. 2008;86:1702–6.

    Article  PubMed  Google Scholar 

  19. Oto T. Lung transplantation from donation after cardiac death (non-heart-beating) donors. Gen Thorac Cardiovasc Surg. 2008;56:533–8.

    Article  PubMed  Google Scholar 

  20. Van Raemdonck DE, Jannis NC, De Leyn PR, Flameng WJ, Lerut TE. Warm ischemic tolerance in collapsed pulmonary grafts is limited to 1 hour. Ann Surg. 1998;228:788–96.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Egan TM. Non-heart-beating donors in thoracic transplantation. J Heart Lung Transplant. 2004;23:3–10.

    Article  PubMed  Google Scholar 

  22. Rega FR, Neyrinck AP, Verleden GM, Lerut TE, Van Raemdonck DE. How long can we preserve the pulmonary graft inside the non-heart-beating donor? Ann Thorac Surg. 2004;77:438–44.

    Article  PubMed  Google Scholar 

  23. Rega FR, Jannis NC, Verleden GM, Flameng WJ, Lerut TE, Van Raemdonck DE. Should we ventilate or cool the pulmonary graft inside the non-heart-beating donor? J Heart Lung Transplant. 2003;22:1226–33.

    Article  PubMed  Google Scholar 

  24. Binns OA, DeLima NF, Buchanan SA, Mauney MC, Cope JT, Thies SD, et al. Impaired bronchial healing after lung donation from non-heart-beating donors. J Heart Lung Transplant. 1996;15:1084–92.

    CAS  PubMed  Google Scholar 

  25. Miyoshi K, Oto T, Otani S, et al. Effect of donor pre-mortem hypoxia and hypotension on graft function and start of warm ischemia in donation after cardiac death lung transplantation. J Heart Lung Transplant. 2011;30:445–51.

    Article  PubMed  Google Scholar 

  26. Otani S, Oto T, Kakishita T, et al. Early effects of the ex vivo evaluation system on graft function after swine lung transplantation. Eur J Cardiothorac Surg. 2011;40:956–61.

    PubMed  Google Scholar 

  27. Yeung JC, Cypel M, Machuca TN, et al. Physiologic assessment of the ex vivo donor lung for transplantation. J Heart Lung Transplant. 2012;31:1120–6.

    Article  PubMed  Google Scholar 

  28. Geudens N, Van de Wauwer C, Neyrinck AP, Timmermans L, Vanhooren HM, Vanaudenaerde BM, et al. N-acetyl cysteine pre-treatment attenuates inflammatory changes in the warm ischemic murine lung. J Heart Lung Transplant. 2007;26:1326–32.

    Article  PubMed  Google Scholar 

  29. Oto T, Calderone A, Pepe S, Snell G, Rosenfeldt F. High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemia. J Thorac Cardiovasc Surg. 2006;132:413–9.

    Article  PubMed  Google Scholar 

  30. Yoshida S, Sekine Y, Shinozuka N, Satoh J, Yasufuku K, Iwata T, et al. The efficacy of partial liquid ventilation in lung protection during hypotension and cardiac arrest: preliminary study of lung transplantation using non-heart-beating donors. J Heart Lung Transplant. 2005;24:723–9.

    Article  PubMed  Google Scholar 

  31. Wittwer T, Franke UF, Sandhaus T, Groetzner J, Strauch JT, Wippermann J, et al. Endobronchial donor pre-treatment with ventavis: is a second administration during reperfusion beneficial to optimize post-ischemic function of non-heart-beating donor lungs? J Surg Res. 2006;136:136–42.

    Article  CAS  PubMed  Google Scholar 

  32. Chen F, Nakamura T, Fujinaga T, Zhang J, Hamakawa H, Omasa M, et al. Protective effect of a nebulized beta2-adorenoreceptor agonist in warm ischemic-reperfused rat lungs. Ann Thorac Surg. 2006;82:465–71.

    Article  PubMed  Google Scholar 

  33. Egan TM, Hoffmann SC, Sevala M, Sadoff JD, Schlidt SA. Nitroglycerin reperfusion reduces ischemia-reperfusion injury in non-heart-beating donor lungs. J Heart Lung Transplant. 2006;25:110–9.

    Article  PubMed  Google Scholar 

  34. Takashima S, Koukoilis G, Inokawa H, Sevala M, Egan TM. Inhaled nitric oxide reduces ischemia-reperfusion injury in rat lungs from non-heart-beating donors. J Thorac Cardiovasc Surg. 2006;132:132–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmacological Sciences, 2-5-1, Shikata-cho, Okayama, Kita-ku, 700-8558, Japan

    Takahiro Oto

Authors
  1. Takahiro Oto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takahiro Oto .

Editor information

Editors and Affiliations

  1. Department of Surgery and Clinical Research Center, Chiba-East National Hospital,, Chiba, Japan

    Takehide Asano

  2. Department of Therapeutics for End-Stage Organ Dysfunction, Osaka University Graduate School of Medicine, Suita, Osaka, Japan

    Norihide Fukushima

  3. Department of Organ Transplant Surgery, Fujita Health University, Aichi, Japan

    Takashi Kenmochi

  4. Division for Innovative Surgery and Transplantation, National Center for Child Health and Development, Setagaya-ku, Tokyo, Japan

    Naoto Matsuno

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Japan

About this chapter

Cite this chapter

Oto, T. (2014). DCD for Lung Transplantation. In: Asano, T., Fukushima, N., Kenmochi, T., Matsuno, N. (eds) Marginal Donors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54484-5_6

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54484-5_6

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54483-8

  • Online ISBN: 978-4-431-54484-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation