Abstract
Among the exocrine tumors of the pancreas, intraductal papillary mucinous neoplasms (IPMNs) have gained increasing attention in the last decade. MD-IPMNs are predominantly (>50 %) composed of intestinal-type epithelium, producing thick mucus. In similarity to other epithelial neoplasms, MD-IPMN follows an “adenoma–carcinoma sequence” with progression into invasive cancer over the course of several years. On average, patients with malignant MD-IPMN are 4–6 years older than those with low- to moderate-grade dysplasia. There are no reliable predictors of malignancy for patients with MD-IPMN, although several studies have described clinical and radiologic features that are more common in MD-IPMN carcinoma. Like in ductal adenocarcinoma of the pancreas, jaundice and a recent onset or deterioration of diabetes mellitus are highly suspicious for malignancy. Significant effort has been made to understand the molecular pathogenesis of MD-IPMNs. Various molecular characteristics have been described in both MD-IPMN and BD-IPMN carcinoma, showing numerous parallels to conventional ductal carcinoma of the pancreas.
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Sahora, K., Castillo, C.Fd. (2014). Natural History and Malignant Change of Main Duct IPMN. In: Tanaka, M. (eds) Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54472-2_2
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DOI: https://doi.org/10.1007/978-4-431-54472-2_2
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