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Opportunities and Challenges for LVAD Therapy Now and in the Future

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Ventricular Assist Devices in Advanced-Stage Heart Failure

Abstract

Left ventricular assist devices (LVADs) are increasingly being used to support patients suffering from advanced heart failure . Efficacy has been proven in prospective controlled trials. Observations from registries and clinical experiences all suggest improving mortality , morbidity , and costs. Global expansion of the technology serves as tacit endorsement of these notions. The large gap between actual and projected potential use can be partially explained by improvements in medical therapy for heart failure and heart transplantation as well as the biological limitations of the implanted machines and their relationship to the retained native heart . Improvements in the near future will focus improving clinical management strategies and the introduction of full implantable systems . Ultimately pumps which have a more intimate relationship both to the retained heart and host will be necessary to improve results. This will include the introduction of pulsatility and the reduction of shear stress and the use of more bio-friendly materials.

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Authors and Affiliations

  1. Sharp Memorial Hospital, San Diego, CA, USA

    Walter P. Dembitsky & Robert M. Adamson

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  1. Walter P. Dembitsky
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  2. Robert M. Adamson
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Correspondence to Walter P. Dembitsky .

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Editors and Affiliations

  1. Dept. of The Therapeutic Strategy for Heart Failure, The University of Tokyo Hospital, Graduate School of Medicine, The University of Tokyo, Tokyo, Tokyo, Japan

    Shunei Kyo

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Dembitsky, W.P., Adamson, R.M. (2014). Opportunities and Challenges for LVAD Therapy Now and in the Future. In: Kyo, S. (eds) Ventricular Assist Devices in Advanced-Stage Heart Failure. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54466-1_1

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  • DOI: https://doi.org/10.1007/978-4-431-54466-1_1

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  • Print ISBN: 978-4-431-54465-4

  • Online ISBN: 978-4-431-54466-1

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