Abstract
A dose-escalation clinical trial was first initiated in 1996 to evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) for inoperable bone and soft-tissue sarcomas. The dose-escalation trial and a subsequent fixed-dose trial on patients with non-metastatic sarcomas revealed that carbon ion radiotherapy provided good local control and offered a survival advantage with acceptable levels of morbidity. Ninety-five percent of the patients enrolled in the trials had axial sarcomas. The 3- and 5-year local control rates of the entire study population in the fixed-dose trial were 79 and 71 %, respectively, with the corresponding 3- and 5-year overall survival rates being 71 and 59 %. As of March 2013, over 900 patients were treated with carbon ion radiotherapy for bone and soft-tissue sarcomas in several trials. The most commonly treated sarcoma was sacral chordoma, followed by axial high-grade bone and soft-tissue sarcomas. This chapter deals with C-ion RT for unresectable sarcomas below C2.
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Imai, R. (2014). Bone and Soft-Tissue Sarcomas. In: Tsujii, H., Kamada, T., Shirai, T., Noda, K., Tsuji, H., Karasawa, K. (eds) Carbon-Ion Radiotherapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54457-9_31
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DOI: https://doi.org/10.1007/978-4-431-54457-9_31
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