A Process Algebra Model of Interleukin-2 Trafficking in Hematopoeitic Cells

  • John Justine S. Villar
  • Adrian Roy L. Valdez
Conference paper
Part of the Proceedings in Information and Communications Technology book series (PICT, volume 7)


Interleukin-2 (IL-2) is a signaling molecule involved in the development of cellular immunity, and has also been identified as an important regulator in cell proliferation and differentiation in hematopoeitic cells. Furthermore, this has been explored as means of treatment in several disorders, such as melanoma and kidney cancer, among others. In this paper, a model of IL-2 trafficking is presented using stochastic π-calculus. π-calculus is a process algebra that allows the components of a biological system to be modeled independently, rather than modeling the individual reactions. The model simulation is carried out using Stochastic Pi Machine (SPiM), an implementation of stochastic π-calculus using the Gillespie’s algorithm. The proposed model will illustrate the behavior of the ligand system and identify various processes that influence its dynamics.


stochastic π-calculus Interleukin-2 process algebra model 


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Copyright information

© Springer Tokyo 2013

Authors and Affiliations

  • John Justine S. Villar
    • 1
  • Adrian Roy L. Valdez
    • 2
  1. 1.Institute of MathematicsUniversity of the Philippines DilimanPhilippines
  2. 2.Department of Computer ScienceUniversity of the Philippines DilimanPhilippines

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