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Epigenetics in Endometriosis

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Endometriosis

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Abstract

There is accumulating evidence supporting the concept that endometriosis is a disease associated with an epigenetic disorder. Epigenetics is one of the most expanding fields in the current biomedical research. The word “epigenetics” refers to the study of mitotically and/or meiotically heritable changes in gene expression that occur without changes in the DNA sequence. The disruption of such changes (epigenetic aberration or disorder) underlies a wide variety of pathologies. Epigenetic regulation includes DNA methylation and histone modifications and is responsible for a number of gene transcriptions associated with chromatin modifications that distinguish the states of diseases. As an introduction, we summarize our findings of epigenetic disorder in endometriotic cells and then overview recent studies focused on DNA methylation in endometriosis. We describe our recent challenge and advanced studies from other laboratories using genome-wide (GW) analysis. Finally, we refer to environmental factors as a potential background of epigenetic disorder in endometriosis.

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Acknowledgment

This work was supported in part by Grants-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science (Nos. 22591824 and 18591800 to M.I.).

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  1. Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, 683-8504, Japan

    Masao Izawa Ph.D., Fuminori Taniguchi & Tasuku Harada

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  1. Masao Izawa Ph.D.
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  2. Fuminori Taniguchi
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  3. Tasuku Harada
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Correspondence to Masao Izawa Ph.D. .

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  1. Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Tottori, Japan

    Tasuku Harada

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Izawa, M., Taniguchi, F., Harada, T. (2014). Epigenetics in Endometriosis. In: Harada, T. (eds) Endometriosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54421-0_8

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