Abstract
An extremely diverse spectrum of diseases can cause salivary gland swelling. Disorders termed Mikulicz’s disease and Küttner’s tumor have long been recognized as chronic inflammatory conditions for more than a century and regarded as separate conditions, both associated with painless non-tumorous lesions of the salivary glands. Lacrimal gland swelling is also associated with Mikulicz’s disease, which for more than 50 years was considered erroneously to be a subtype of Sjögren’s syndrome. Developments in recent years have made it clear that although disorders such as Sjögren’s syndrome, sarcoidosis, lymphoma, and others can cause swelling of the salivary and lacrimal glands, Mikulicz’s disease is a distinct subset of IgG4-related disease (IgG4-RD). Many patients previously diagnosed with Küttner’s tumors, or chronic sclerosing submandibular sialadenitis, also in fact have IgG4-RD. These conditions are associated with characteristic histopathological features, increased concentrations of IgG4-bearing plasma cells in affected organs, and often elevated levels of IgG4 in serum. In this chapter, we outline clinical aspects of these two conditions, including their historical background.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Mikulicz J. über eine eigenartige symmetrishe erkrankung der tranen und mundspeicheldrüsen. Beitr Chir Fesrschr Theodor Billroth. 1982;610–30
Schaffer AJ, Jacobsen AW. Mikulicz’s syndrome: a report of ten cases. Am J Dis Child. 1927;34:327–46.
Sjögren H. Zur Kenntnis der Keratoconjunctivitis Sicca. Acta Ophthalmol. 1933;11 Suppl 2:1–151.
Morgan WS, Castleman B. A clinicopathologic study of Mikulicz’s disease. Am J Pathol. 1953;29:471–503.
Yamamoto M, Suzuki C, Naishiro Y, et al. The significance of disease-independence in Mikulicz’s disease-Revival interests in Mikulicz’s disease. Jpn J Clin Immunol. 2006;29:1–7.
Küttner H. über entzündliche Tumoren der submaxillar Speicheldrüse. Bruns Beitr Klin Chir. 1886;8:815–28.
Kitagawa S, Funata N, Harada K, et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Küttner’s tumor). Am J Surg Pathol. 2005;29:783–91.
Miyamoto M, Yoshihara T. A serological and pathological study of IgG4-related plasmacytic disease: Mikulicz’s disease and chronic sclerosing sialadentis of the submandibular gland( Küttner’s tumor). Pract Oto-Rhino-Laryngol. 2012;105:267–76.
Konno A, Ito E, Okamoto Y. The clinical, histopathological and electronmicroscopical study of chronic parotitis Sjögren syndrome and Mikulicz disease. Symp Salivary Gland. 1984;25:1–33.
Seifert G, Donath K. Zur pathogenese des küttner-tumors der submandibularis. Analyse von 349 fällen mit chronischer sialadenitis der submandibularis. HNO. 1977;25:81–92.
Yoshihara T, Kanda T, Yaku Y, et al. Chronic sialadenitis of the submandibular gland (so- called Küttner tumor). Auris Nasus Larynx. 1983;10:117–23.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Japan
About this chapter
Cite this chapter
Yoshihara, T., Miyamoto, M. (2014). Salivary Gland Lesions in Mikulicz’s Disease and Küttner’s Tumor. In: Umehara, H., Okazaki, K., Stone, J., Kawa, S., Kawano, M. (eds) IgG4-Related Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54228-5_5
Download citation
DOI: https://doi.org/10.1007/978-4-431-54228-5_5
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54227-8
Online ISBN: 978-4-431-54228-5
eBook Packages: MedicineMedicine (R0)