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Chembiomolecular Science pp 145–153Cite as

Roles for the Stress-Responsive Kinases ASK1 and ASK2 in Tumorigenesis

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Abstract

Eukaryotic cells sense a wide range of biological and physicochemical stressors from both external and internal environments and convert them to physiological signals that lead to appropriate responses. Some stressors cause cellular damage, resulting in the activation of the cellular repair mechanism. In cases of severe damage, cells undergo apoptosis, which prevents uncontrollable cell proliferation. Stress-responsive signaling pathways elaborately regulate this defense mechanism against cytotoxic stressors, and their dysfunction can lead to tumorigenesis. Most of these pathways are also activated during inflammatory responses that, while intrinsically host defensive, increase the risk of tumorigenesis, especially when the response is chronic. Therefore, the stress-responsive signaling pathways that regulate apoptosis and inflammation are important as research subjects to explore the mechanisms of tumorigenesis and as therapeutic targets of cancer.

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Authors and Affiliations

  1. Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Miki Kamiyama, Takehiro Sato & Hidenori Ichijo

  2. Division of Cell Regulation, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki, 852-8521, Japan

    Kohsuke Takeda

Authors
  1. Miki Kamiyama
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  2. Takehiro Sato
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  3. Kohsuke Takeda
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  4. Hidenori Ichijo
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Corresponding author

Correspondence to Hidenori Ichijo .

Editor information

Editors and Affiliations

  1. Institute of Microbial Chemistry, Kamioosaki 3-14-23, Tokyo, 141-0021, Japan

    Masakatsu Shibasaki

  2. The University of Tokyo, Department of Pharmacology, Graduate School of Medicine, Hongo 7-3-1, Bunkyo-ku, 113-0033, Japan

    Masamitsu Iino

  3. RIKEN Advanced Science Institute, Antibiotics Laboratory, Chemical Biology Core Facility, 2-1, Hirosawa, Wako, 351-0198, Saitama, Japan

    Hiroyuki Osada

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© 2012 Springer

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Kamiyama, M., Sato, T., Takeda, K., Ichijo, H. (2012). Roles for the Stress-Responsive Kinases ASK1 and ASK2 in Tumorigenesis. In: Shibasaki, M., Iino, M., Osada, H. (eds) Chembiomolecular Science. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54038-0_14

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