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Inhibitory Effects of Phytoestrogens and Related Herbal Extracts on Mouse Endometrial Carcinogenesis: A Review

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Cell and Molecular Biology of Endometrial Carcinoma

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Summary

The effects of isofiavones (genistein and daidzein) and related Kampo medicines (Juzen-taiho-to and Shimotsu-to) on endometrial carcinogenesis in mice were investigated separately in two experiments. In the short-term experiment (2 weeks), a single subcutaneous (s.c.) administration of genistein [(lmg/30g body weight (BW))] significantly decreased the levels of 17β-estradiol (E2; 5p.p.m. in diet)induced expression of c-jun, interleukin (IL)-1α and tumor necrosis factor (TNF)-α mRNAs in the uteri of ovariectomized mice (P < 0.005, P < 0.05, and P < 0.01, respectively). Daidzein significantly inhibited E2-induced expression of c-fos and IL-1α (P < 0.01 and P < 0.01, respectively). In the long-term experiment (30 weeks), the incidences of endometrial adenocarcinoma and atypical endometrial hyperplasia were significantly lower in the E2 group treated with either genistein or daidzein than in the corresponding control group (P < 0.01 and P < 0.05, respectively). In the shortterm experiment, Juzen-taiho-to or Shimotsu-to (Kampo formula) treatment (2 weeks) significantly decreased the levels of E2-stimulated expression of c-fos mRNA (P < 0.05). In the long-term experiment, Juzen-taiho-to and Shimotsu-to treatment significantly decreased the incidences of endometrial adenocarcinoma (P < 0.05) and other preneoplastic lesions under estrogenic stimulation. It is suggested that both genistein and daidzein, as well as Juzen-taiho-to, have an inhibitory effect on estrogen-related endometrial carcinogenesis in mice, indicated by the suppression of estrogen-related c-fos and c-jun, as well as the suppression of cytokine IL-1α and TNF-α-expression through a cytokine- and estrogen receptor-mediated pathway. Shimotsu-to is considered to be a key compounet of Juzen-taiho-to for the prevention of endometrial carcinoma.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasamachi, Gifu, 500-8705, Japan

    Kenji Niwa, Zenglin Lian, Keiko Tagami, Jingchun Gao & Teruhiko Tamaya

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  1. Kenji Niwa
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  2. Zenglin Lian
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  3. Keiko Tagami
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  4. Jingchun Gao
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  5. Teruhiko Tamaya
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Editors and Affiliations

  1. Department of Clinical Cytology, Graduate School of Medical Sciences, Kitasato University, 1-15-1 Kitasato, Sagamihara, Kanagawa, 228-8555, Japan

    Hiroyuki Kuramoto M.D., Ph.D. (Professor) (Professor)

  2. Kasumigaura National Hospital, 2-7-14 Shimotakatsu, Tsuchiura, Ibaraki, 300-8585, Japan

    Masato Nishida M.D., Ph.D. (President) (President)

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© 2003 Springer Japan

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Niwa, K., Lian, Z., Tagami, K., Gao, J., Tamaya, T. (2003). Inhibitory Effects of Phytoestrogens and Related Herbal Extracts on Mouse Endometrial Carcinogenesis: A Review. In: Kuramoto, H., Nishida, M. (eds) Cell and Molecular Biology of Endometrial Carcinoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53981-0_12

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  • DOI: https://doi.org/10.1007/978-4-431-53981-0_12

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67977-6

  • Online ISBN: 978-4-431-53981-0

  • eBook Packages: Springer Book Archive

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