Abstract
Inflammatory processes are believed to participate in the pathogenesis of traumatic brain and spinal cord injury (SCI) [4,9,11].Strategies that target inflammation after neurotrauma have been reported to improve outcome. Of interest to the present discussion is the fact that therapeutic hypothermia has been reported to reduce the accumulation of polymorphonuclear leukocytes (PMNLs) after cerebral ischemia and trauma [10,12,13]. In a study of transient middle cerebral artery occlusion, postischemic hypothermia delayed neutrophil accumulation and microglial activation [6]. Following control cortical impact injury, Whalen and colleagues [12] reported that PMNL accumulation in the injured cortex after 4h was significantly decreased in rats maintained at 32°C vs 39°C. Chatzipanteli and colleagues [2] have demonstrated that hypothermia (32°C) after moderate F-P brain injury also reduces the degree of PMNL accumulation in damaged areas at 3h and 3 days after traumatic brain injury (TBI).
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© 2004 Springer Japan
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Hayashi, N., Dietrich, D.W. (2004). Inflammation. In: Brain Hypothermia Treatment. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53953-7_18
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DOI: https://doi.org/10.1007/978-4-431-53953-7_18
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