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Adult Neurogenesis in Epilepsy

  • Chapter
Neurogenesis in the Adult Brain II

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Abstract

Epilepsy is a devastating illness affecting about 50 million people worldwide that disturbs multiple aspects of brain integrity and function. Epileptic seizures may not only lead to degeneration of affected areas but also strongly induces the birth of new neurons generated by adult neural stem cells (NSCs) in the two neurogenic areas of the adult brain, the hippocampal dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. In this chapter, we focus on mesial temporal lobe epilepsy (mTLE), which is the most common and often intractable form of acquired epilepsy. We will review and discuss recent data derived from rodent models of mTLE and human samples analyzing the effects of epileptic activity on NSC activity, neuronal differentiation and integration, and the potential role that newborn neurons may play in the epileptic disease process.

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Authors and Affiliations

  1. Department of Biology, Institute of Cell Biology, Swiss Federal Institute of Technology (ETH) Zürich, Schafmattstrasse 18, 8093, Zurich, Switzerland

    Sebastian Jessberger

  2. Department of Neurology, University of Michigan, 109 Zina Pitcher Place 5021 BSRB, Ann Arbor, MI, 48109, USA

    Jack M. Parent

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Correspondence to Sebastian Jessberger or Jack M. Parent .

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Editors and Affiliations

  1. Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160-8402, Japan

    Tatsunori Seki Ph.D. (Professor) (Professor)

  2. Department of Developmental and Regenerative Biology, Institute of Molecular Medicine Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Kazunobu Sawamoto Ph.D. (Professor) (Professor)

  3. Department of Neurology, University of Michigan, 109 Zina Pitcher Place 5021 BSRB, Ann Arbor, MI, 48109, USA

    Jack M. Parent M.D. (Associate Professor) (Associate Professor)

  4. Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, 94143, USA

    Arturo Alvarez-Buylla Ph.D. (Professor) (Professor)

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Jessberger, S., Parent, J.M. (2011). Adult Neurogenesis in Epilepsy. In: Seki, T., Sawamoto, K., Parent, J.M., Alvarez-Buylla, A. (eds) Neurogenesis in the Adult Brain II. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53945-2_3

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