Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum

  • Makoto Endo
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 592)


In early 1960s clear evidence was presented by Professor S. Ebashi for the fact that contraction-relaxation cycle of living muscle is regulated by calcium ion (Ca2+) (cf. Ebashi and Endo, 1968). He then inquired into the mechanism of the action of Ca2+ and disclosed that the regulation of contractile reaction by Ca2+ requires the presence of a protein component other than myosin and actin (Ebashi, 1963). A few years later, he showed that the protein component is a complex of a known protein, tropomyosin, and a new protein, troponin (Ebashi and Kodama, 1965).


Skeletal Muscle Sarcoplasmic Reticulum Ryanodine Receptor Malignant Hyperthermia Malignant Hyperthermia 
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Copyright information

© Springer 2007

Authors and Affiliations

  • Makoto Endo
    • 1
  1. 1.Faculty of Medical Care and HealthSaitama Medical UniversityKawagoeJapan

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