Calcium-Induced Release of Calcium From the Sarcoplasmic Reticulum
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In early 1960s clear evidence was presented by Professor S. Ebashi for the fact that contraction-relaxation cycle of living muscle is regulated by calcium ion (Ca2+) (cf. Ebashi and Endo, 1968). He then inquired into the mechanism of the action of Ca2+ and disclosed that the regulation of contractile reaction by Ca2+ requires the presence of a protein component other than myosin and actin (Ebashi, 1963). A few years later, he showed that the protein component is a complex of a known protein, tropomyosin, and a new protein, troponin (Ebashi and Kodama, 1965).
KeywordsSkeletal Muscle Sarcoplasmic Reticulum Ryanodine Receptor Malignant Hyperthermia Malignant Hyperthermia
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