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Nuclear Dynamics pp 197–226Cite as

Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear Domains

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Abstract

The driving force behind studies on nuclear architecture is based on the assumption that nuclear architecture is an integrated part of the complex epigenetic regulatory mechanisms which control cell type specific gene expression patterns. Epigenetic mechanisms comprise the chromatin level, including DNA methylation, histone modifications and chromatin remodeling factors, and the nuclear level, which includes the dynamics and three-dimensional (3D) spatial higher-order organization of the genome inside the cell nucleus. There is increasing evidence that such a higher-order organization of chromatin arrangement contributes essentially to the regulation of gene expression and other nuclear functions (for review see Spector 2003; van Driel et al. 2003).

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Authors and Affiliations

  1. Department of Cellular Biology, Research Institute for Radiation Biology and medicine, Hiroshima University, Kasumi 1-2-3, Hiroshima, 734-8553, Japan

    Satoshi Tashiro

  2. Department of Biology II, Ludwig Maximilians University (LMU), Grosshadernerstr. 2, D-82152, Martinsried, Germany

    Marion Cremer, Irina Solovei & Thomas Cremer

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  1. Satoshi Tashiro
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  2. Marion Cremer
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  3. Irina Solovei
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  4. Thomas Cremer
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Editors and Affiliations

  1. Department of Infection Biology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennohdai, Tsukuba, Ibaraki, 305-8575, Japan

    Kyosuke Nagata Ph.D. (Professor) (Professor)

  2. Laboratory of Plasma Membrane and Nuclear Signaling, Kyoto University Graduate School of Biostudies, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan

    Kunio Takeyasu (Dr.Sci., Professor) (Dr.Sci., Professor)

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Tashiro, S., Cremer, M., Solovei, I., Cremer, T. (2007). Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear Domains. In: Nagata, K., Takeyasu, K. (eds) Nuclear Dynamics. Springer, Tokyo. https://doi.org/10.1007/978-4-431-30130-1_9

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