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Regulation of Chromatin Structure by Curved DNA: How Activator Binding Sites Become Accessible

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Nuclear Dynamics

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Abstract

A single somatic cell of humans contains DNA fibers of a total length of approximately 2 m, which are compacted, without entanglement, into the nucleus of approximately 1×10−5 m in diameter. To greater or lesser degrees, all organisms compact their DNA. Biologically important DNA regions, such as the origins of DNA replication, regulatory regions of transcription, and recombination loci, must all be compacted. The tightly constrained DNA, however, presents the appropriate environment for replication, transcription, and recombination to take place.

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Authors and Affiliations

  1. Department of Biology, Faculty of Education and Integrated Arts and Sciences, Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, 1-6-1, Nishi-Waseda, Shinjuku-ku, Tokyo, 169-8050, Japan

    Takashi Ohyama

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  1. Takashi Ohyama
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Editors and Affiliations

  1. Department of Infection Biology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennohdai, Tsukuba, Ibaraki, 305-8575, Japan

    Kyosuke Nagata Ph.D. (Professor) (Professor)

  2. Laboratory of Plasma Membrane and Nuclear Signaling, Kyoto University Graduate School of Biostudies, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan

    Kunio Takeyasu (Dr.Sci., Professor) (Dr.Sci., Professor)

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Ohyama, T. (2007). Regulation of Chromatin Structure by Curved DNA: How Activator Binding Sites Become Accessible. In: Nagata, K., Takeyasu, K. (eds) Nuclear Dynamics. Springer, Tokyo. https://doi.org/10.1007/978-4-431-30130-1_10

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