Skip to main content

Evolution von Medikamentenresistenzen

  • Chapter
Evolutionsbiologie

Zusammenfassung

Wenn wir das Wort „Evolution“ hören, denken wir oft an Charles Darwin und sein berühmtes Werk „Die Entstehung der Arten“; oder wir haben die Entwicklung des Menschen und seiner nächsten Verwandten, der Menschenaffen, im Sinn. Evolution ist jedoch nicht einfach etwas, das vor langer Zeit geschehen ist. Evolution geschieht hier und jetzt und ist von großer Bedeutung für unser tägliches Leben. Wenn beispielsweise bei einem Krebskranken die Chemotherapie keine Wirkung mehr zeigt, liegt das wahrscheinlich an der Evolution der Tumorzellen. In diesem Fall kann Evolution für uns zur tödlichen Gefahr werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 49.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • O’Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, Lechner K, Nielsen JL, Rousselot P, Reiffers J, Saglio G, Shepherd J, Simonsson B, Gratwohl A, Goldman JM, Kantarjian H, Taylor K, Verhoef G, Bolton AE, Capdeville R, Druker BJ (2003) Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 348: 994–1004

    Article  PubMed  Google Scholar 

  • Coia JE, Duckworth GJ, Edwards DI, Farrington M, Fry C, Humphreys H, Mallaghan C, Tucker DR (2006) Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J Hosp Infec 63: S1-S44

    Article  Google Scholar 

  • Erdpunkte.de (2010) Klima Kambodscha. URL http://www.erdpunkte.de/klima-kambodscha.html [16.12.2010]

  • Franco-Paredes C, Santos-Preciado J (2006) Problem pathogens: prevention of malaria in travelers. Lancet Infect Dis 6: 139–149

    Article  PubMed  CAS  Google Scholar 

  • Goodman LS, Wintrobe MM, Dameshek W, Goodman MJ, Gilman A, McLennan MT (1946) Nitrogen mustard therapy: use of methyl-bis(beta-chloroethyl) amine hydrochloride and tris(beta-chlorethyl) amine hydrochloride for Hodgkin’s disease, lymphosarcoma, leukemia, and certain allied and miscellaneous disorders. JAMA 132:126–132

    CAS  Google Scholar 

  • Goossens H, Ferech M, Vander Stichele R, Elseviers M, ESAC Project Group (2005) Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet 365: 579–587

    PubMed  Google Scholar 

  • Graveland H, Wagenaar JA, Heesterbeek H, Mevius D, van Duijkeren E, Heederik D (2010) Methicillin resistant Staphylococcus aureus ST398 in veal calf farming: human MRSA carriage related with animal antimicrobial usage and farm hygiene. PLoS ONE 5(6): e10990. URL http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010990 [08.11.2010]

  • Hochhaus A, Hehlmann R, Berger U (2003) Chronische myeloische Leukämie: Biologie – Klinik – Diagnostik –Therapie. URL http://www.onkodin.de/e2/e13145/e13166/index_ger.html [08.11.2010]

  • Klevens RM, Morrison MA, Nadle J, Petit S, Gershman K, Ray S, Harrison LH, Lynfield R, Dumyati G, Townes JM, Craig AS, Zell ER, Fosheim GE, McDougal LK, Carey RB, Fridkin SK (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298: 1763–1771

    Article  PubMed  CAS  Google Scholar 

  • Kozal MJ, Kroodsma K, Winters MA, Shafer RW, Efron B, Katzenstein DA, Merigan TC (1994) Didanosine resistance in HIV-infected patients switched from zidovudine to didanosine monotherapy. Ann Intern Med 121: 263–268

    PubMed  CAS  Google Scholar 

  • Larder BA, Kemp SD (1989) Multiple mutations in HIV-1 reverse-transcriptase confer high-level resistance to zidovudine (AZT). Science 246: 1155–1158

    Article  PubMed  CAS  Google Scholar 

  • MayoClinic.com (2010) Chronic myelogenous leukemia. URL http://www.mayoclinic.com/health/medical/IM03579 [08.10.2010]

  • Musset L, Le Bras J, Clain J (2007) Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment. Mol Biol Evol 24: 1582–1585

    Article  PubMed  CAS  Google Scholar 

  • National Science Foundation (NSF) (2010) Science and engineering indicators 2010. URL http://www.nsf.gov/statistics/seind10/start.htm [16.12.2010]

  • Palumbi SR (2001) Humans as the world’s greatest evolutionary force. Science 293: 1786–1790

    Article  PubMed  CAS  Google Scholar 

  • Read AF, Huijben S (2009) Evolutionary biology and the avoidance of antimicrobial resistance. Evol Appl 2: 40–51

    Article  Google Scholar 

  • Reiss P, Lange JMA, Boucher CA, Danner SA, Goudsmit J (1988) Resumption of HIV antigen production during continuous zidovudine treatment. Lancet 1: 420–421

    Google Scholar 

  • Roper C, Pearce R, Nair S, Sharp B, Nosten F, Anderson T (2004) Intercontinental spread of pyrimethamine-resistant malaria. Science 305: 1124

    Article  PubMed  CAS  Google Scholar 

  • The Antiretroviral Therapy Cohort Collaboration (2008) Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 372: 293–299

    Article  Google Scholar 

  • World Health Organization (WHO) (2006) World cancer day: global action to avert 8 million cancerrelated deaths by 2015. URL http://www.who.int/mediacentre/news/releases/2006/pr06/en/index.html [08.11.2010]

  • World Health Organiszation (WHO) (2008) Anti-tuberculosis drug resistance in the world, Report No. 4. URL http://whqlibdoc.who.int/hq/2008/WHO_HTM_TB_2008.394_eng.pdf [08.11.2010]

  • World Health Organization (WHO) (2010a) Strategy paper on management of antimalarial drug resistance for the roll back malaria (RBM) Board, 17th Meeting, 2–4 December 2009, Global Malaria Programme. URL http://www.rollbackmalaria.org/partnership/wg/wg_management/docs/RBMStrategy_AntimalarialDrugResistance.pdf [05.11.2010]

  • World Health Organization (WHO) (2010b) Malaria epidemiology, Cambodia. URL http://www.wpro.who.int/sites/mvp/epidemiology/malaria/cam_maps.htm [16.12.2010]

  • World Health Organization (WHO) (2010c) Progress on the containment of Artemisinin tolerant malaria parasites in South-East Asia (ARCE) Initiative. URL http://www.who.int/malaria/diagnosis_treatment/resistance/Malaria_brief_containment_project_apr10_11_en.pdf [22.12.2010]

  • Wikipedia (2010a) Humanes Immundefizienz-Virus. URL http://de.wikipedia.org/wiki/Humanes_Immundefizienz-Virus [06.10.2010]

  • Wikipedia (2010b) Staphyloccocus aureus. URL http://de.wikipedia.org/wiki/Staphylococcus_aureus [08.11.2010]

  • Wisplinghoff H, Ewertz B, Wisplinghoff S, Stefanik D, Plum G, Perdreau-Remington F, Seifert H (2005) Molecular evolution of methicillin-resistant Staphylococcus aureus in the metropolitan area of Cologne, Germany, from 1984 to 1998. J Clin Microbiol 43: 5445–5451

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Spektrum Akademischer Verlag Heidelberg

About this chapter

Cite this chapter

Meredith, R., Wittmann, M., Pennings, P. (2011). Evolution von Medikamentenresistenzen. In: Dreesmann, D.C., Graf, D., Witte, K. (eds) Evolutionsbiologie. Spektrum Akademischer Verlag. https://doi.org/10.1007/978-3-8274-2786-1_5

Download citation

Publish with us

Policies and ethics