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Die lymphatischen Organe: Blutbildung und Konferenzzentren

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Immunologie für Einsteiger

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Zusammenfassung

Die Träger der angeborenen und adaptiven Immunantwort sind die weißen Blutkörperchen, die Leukocyten. Sie zirkulieren in unserem Blut, wandern als Wachposten in unsere Gewebe, schlagen Alarm, wenn Eindringlinge in unseren Körper gelangen, wehren sie ab, kommunizieren untereinander mithilfe löslicher Stoffe, reparieren Wunden und machen uns schließlich immun. Doch wo kommen sie her, die Leukocyten, unsere Körperpolizei? Wann lernen Sondereinheiten dieser Zellen Pathogene abzuwehren, aber eigene Strukturen dagegen zu schonen? Wo treffen sie sich, um eine adaptive Immunantwort einzuleiten?

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Literatur

  • Butcher EC, Picker LJ (1996) Lymphocyte homing and homeostasis. Science 272: 60–66

    Article  PubMed  CAS  Google Scholar 

  • Campbell JJ, Butcher EC (2000) Chemokines in tissue specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 12: 336–341

    Article  PubMed  CAS  Google Scholar 

  • Campbell JJ, Pan J, Butcher EC (1999) Cutting edge: developmental switches in chemokine responses during T cell maturation. J Immunol 163: 2353–2357

    PubMed  CAS  Google Scholar 

  • Ciofani M, Knowles GC, Wiest FL, Boehmer H von, Zuniga-Pflücker JC (2006) Stage-specific and differential notch dependency at the aß and the ψδ T lineage bifurcation. Immunity 25: 105–116

    Article  PubMed  CAS  Google Scholar 

  • Cyster JG (2000) Leukocyte migration: scent of the T zone. Curr Biol 10: R30–R33

    Article  PubMed  CAS  Google Scholar 

  • Ebert LM, Schaerli P, Moser B (2004) Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol Immunol 42: 799–809

    Article  PubMed  Google Scholar 

  • Fu W, Chen W (2004) Roles of chemokines in thymopoiesis: Redundancy and regulation Cell Mol Immunol 1: 266–273

    PubMed  CAS  Google Scholar 

  • Holtmeier W, Kabelitz D (2005) Gammadelta T cells link innate and adaptive immune responses. Chem Immunol Allergy 86: 151–183

    Article  PubMed  CAS  Google Scholar 

  • Kirchner H, Kruse A, Neustock P, Rink L (1993) Cytokine und Interferone: Botenstoffe des Immunsystems. Spektrum Akademischer Verlag, Heidelberg

    Google Scholar 

  • Laird DJ, von Andrian UH, Wagers AJ (2008) Stem cell trafficking in tissue development, growth and disease. Cell 132: 612–630

    Article  PubMed  CAS  Google Scholar 

  • Melchers F, ten Boekel E, Seidl T, Kong XC, Yamagami T, Onishi K, Shimizu T, Rolink AG, Andersson J (2000) Repertoire selection by pre-B-cell-receptors, and genetic control of B-cell development from immature to mature B-cells. Immunol Rev 175: 33–46

    Article  PubMed  CAS  Google Scholar 

  • Mortellarco A, Wong SC, Fric J, Ricciardi-Castagnoli P (2010) The need to identify myeloid dendritic cell progenitors in human blood. Trends Immunol 31: 18–23

    Article  Google Scholar 

  • Murphy K, Travers P, Walport M (2009) Janeway Immunologie. 7. Aufl. Spektrum Akademischer Verlag, Heidelberg

    Book  Google Scholar 

  • Nemazee D (2006) Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol 6: 728–740

    Article  PubMed  CAS  Google Scholar 

  • Papayannopoulou T (2000) Mechanisms of stem-/progenitor-cell mobilization: the anti-VLA-4 paradigm. Sem Hematol 37: 11–18

    Article  CAS  Google Scholar 

  • Randolph GJ, Angeli V, Swartz MA (2005) Dendritic cell trafficking to lymph nodes through lymphatic vessels. Nat Rev Immunol 5: 617–628

    Article  PubMed  CAS  Google Scholar 

  • Raulet DH (2004) Interplay of natural killer cells and their receptors with the adaptive immune response. Nat Immunol 5: 996–1002

    Article  PubMed  CAS  Google Scholar 

  • Raulet DH (2009) Natural Killer cells: Remembrances of things past. Current Biology 19: R294–R296

    Article  PubMed  CAS  Google Scholar 

  • Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, Granucci F, Kraehenbuhl JP, Ricciardi-Castagnoli P (2001) Dendritic cells express tight junctions proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2: 361–367

    Article  PubMed  CAS  Google Scholar 

  • Starr TK, Jameson SC, Hogquist KA (2003) Positive and negative selection of T cells. Annu Rev Immunol 21:139–176

    Article  PubMed  CAS  Google Scholar 

  • Steiniger B, Barth P (2008) Microanatomy and function of the spleen. Advances in Anatomy Embryology and Cell Biology 151, Springer, Berlin, Heidelberg, New York

    Google Scholar 

  • Steiniger B, Barth P, Hellinger A (2001) The perifollicular and marginal zones of the human splenic white pulp: Do fibroblasts guide lymphocyte immigration? Am J Pathol 159: 501–512

    Article  PubMed  CAS  Google Scholar 

  • Xiong N, Raulet DH (2007) Development and selection of ψδ T cells. Immunol Rev 215: 15–31

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institut für Immunologie, Universitätsklinikum Aachen, Deutschland

    Prof. Dr. rer. nat. Lothar Rink & Dr. rer. nat. Hajo Haase

  2. Institut für Systemische Entzündungsforschung, Universitätsklinikum Schleswig-Holstein, Deutschland

    PD Dr. rer. nat. Andrea Kruse

Authors
  1. Prof. Dr. rer. nat. Lothar Rink
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  2. PD Dr. rer. nat. Andrea Kruse
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  3. Dr. rer. nat. Hajo Haase
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© 2012 Spektrum Akademischer Verlag Heidelberg

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Rink, L., Kruse, A., Haase, H. (2012). Die lymphatischen Organe: Blutbildung und Konferenzzentren. In: Immunologie für Einsteiger. Spektrum Akademischer Verlag, Heidelberg. https://doi.org/10.1007/978-3-8274-2440-2_2

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